{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T17:45:05Z","timestamp":1759340705906,"version":"3.40.5"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T00:00:00Z","timestamp":1694217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>Exposure to chemical phenols, which can act as tyrosine analogues and result in anti\u2010melanocyte autoimmunity, has been associated with vitiligo. Acetaminophen (N\u2010acetyl\u2010p\u2010aminophenol) is an over\u2010the\u2010counter analgesic of phenolic origin. The risk of vitiligo with systemic exposure to acetaminophen has not yet been evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We examined the risk of vitiligo with regular use acetaminophen in women, the Nurses' Health Study (NHS) and in men, the Health Professionals Follow\u2010up Study (HPFS). Regular acetaminophen use was asked biennially from 1990 in NHS and from 1986 in HPFS, and the year of clinician\u2010diagnosed vitiligo was asked retrospectively in 2012 in the cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In NHS, a total of 161 vitiligo cases were identified during a follow\u2010up of 571,724 person\u2010years; in HPFS, a total of 183 vitiligo cases were identified during a follow\u2010up of 680,313 person\u2010years. Regular use of acetaminophen was associated with an increased vitiligo risk in NHS but not HPFS. The multivariable relative risk (RR) was 1.52 (95% confidence interval [CI] 1.03\u20132.25) in NHS and 1.09 (95% CI 0.76\u20131.55) in HPFS. The higher risk of vitiligo was similar by duration of acetaminophen use in women; the multivariable RRs were 1.47 (95% CI 0.98\u20132.21) for acetaminophen use under 5\u2009years, and 1.78 (95% CI 1.11\u20132.84) for acetaminophen use over 5\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Acetaminophen may be associated with a higher risk of vitiligo in women.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.14152","type":"journal-article","created":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T07:58:05Z","timestamp":1694246285000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association between acetaminophen use and vitiligo in <scp>US<\/scp> women and men"],"prefix":"10.1111","volume":"64","author":[{"given":"M.","family":"Sachar","sequence":"first","affiliation":[{"name":"Department of Dermatology The Warren Alpert Medical School of Brown University  Providence Rhode Island USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. M.","family":"Lin","sequence":"additional","affiliation":[{"name":"Channing Division of Network Medicine Department of Medicine Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Massachusetts Eye and Ear Infirmary Department of Otolaryngology  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Warren Alpert Medical School of Brown University  Providence Rhode Island USA"},{"name":"Department of Dermatology Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Warren Alpert Medical School of Brown University  Providence Rhode Island USA"},{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education\/Beijing) Department of Cancer Epidemiology Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of California  Davis California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Massachusetts  Worcester Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5468-4589","authenticated-orcid":false,"given":"K.","family":"Ezzedine","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mondor Hospital (AP\u2010HP) Paris Est Cr\u00e9teil University  Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6594-2582","authenticated-orcid":false,"given":"E.","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Warren Alpert Medical School of Brown University  Providence Rhode Island USA"},{"name":"Channing Division of Network Medicine Department of Medicine Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Department of Epidemiology Brown University School of Public Health  Providence Rhode Island USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. A.","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Warren Alpert Medical School of Brown University  Providence Rhode Island USA"},{"name":"Department of Epidemiology Brown University School of Public Health  Providence Rhode Island USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(14)60763\u20107"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100749.2003.00032.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.02.004"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.16"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2016.11.006"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12269"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12402"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.1995.tb00795.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.2007.00989.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2011.356"}],"container-title":["Australasian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.14152","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T08:23:50Z","timestamp":1699518230000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajd.14152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,9]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1111\/ajd.14152"],"URL":"https:\/\/doi.org\/10.1111\/ajd.14152","archive":["Portico"],"relation":{},"ISSN":["0004-8380","1440-0960"],"issn-type":[{"type":"print","value":"0004-8380"},{"type":"electronic","value":"1440-0960"}],"subject":[],"published":{"date-parts":[[2023,9,9]]},"assertion":[{"value":"2022-08-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}