{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:33:24Z","timestamp":1789133604327,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:00:00Z","timestamp":1694563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>Australian data comparing biologic treatments for moderate to severe chronic plaque psoriasis are lacking. We compared persistence on therapy across four biologic therapies (adalimumab, guselkumab, secukinumab and ustekinumab) used to treat chronic plaque psoriasis. The impact of prior biologic use on persistence was also investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort analysis of the Pharmaceutical Benefits Scheme (PBS) 10% sample included data from adult patients prescribed \u22651 biologic of interest by a dermatologist from 1 September 2015 to 31 December 2021. Persistence was defined as continued use until 180\u2009days without a prescription. The index date was the date of the first claim of the biologic. Persistence was evaluated using Kaplan\u2013Meier methods, log\u2010rank tests, adjusted analyses using Cox's regressions, and propensity score matching.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 878 patients, with 1131 index prescriptions, were included. Guselkumab median persistence was not reached in the study period (PBS listed from February 2019). In the adjusted analysis, persistence to guselkumab was significantly greater than to adalimumab (<jats:italic>n<\/jats:italic>\u2009=\u2009105; median 16\u2009months, HR 2.71 (95% CI 1.94\u20133.8), <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), ustekinumab (<jats:italic>n<\/jats:italic>\u2009=\u2009336; median 19\u2009months, HR 2.91 (95% CI 2.22\u20133.82), <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and secukinumab (<jats:italic>n<\/jats:italic>\u2009=\u2009305; median 30\u2009months, HR 1.8 (95% CI 1.36\u20132.38), <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Bio\u2010na\u00efve patients had longer persistence on treatment than bio\u2010experienced patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The nationally representative PBS dataset can provide real\u2010world insights into the persistence on biologic therapies for psoriasis in Australia, where eligibility criteria for reimbursed treatment are stringent. Persistence is an indirect marker of sustained treatment effectiveness and tolerability. Both unadjusted and adjusted analyses found longer persistence for guselkumab compared to adalimumab, secukinumab or ustekinumab.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.14153","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T04:40:11Z","timestamp":1694666411000},"page":"504-513","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Real\u2010world treatment persistence of four commonly prescribed biologic therapies for moderate to severe psoriasis in Australia"],"prefix":"10.1111","volume":"64","author":[{"given":"John","family":"Sullivan","sequence":"first","affiliation":[{"name":"The Sutherland Hospital  Caringbah New South Wales Australia"},{"name":"University of NSW  Kensington New South Wales Australia"},{"name":"Kingsway Dermatology &amp; Aesthetics  Miranda New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Hannam","sequence":"additional","affiliation":[{"name":"Kingsway Dermatology &amp; Aesthetics  Miranda New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Puig","sequence":"additional","affiliation":[{"name":"Janssen Australia  Macquarie Park New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra","family":"Maranta","sequence":"additional","affiliation":[{"name":"Janssen Australia  Macquarie Park New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew B.","family":"McGeachie","sequence":"additional","affiliation":[{"name":"Janssen Australia  Macquarie Park New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Baker","sequence":"additional","affiliation":[{"name":"St Vincent's Hospital  Melbourne Victoria Australia"},{"name":"The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.50591"},{"issue":"3","key":"e_1_2_11_3_1","first-page":"1","article-title":"Psoriasis, depression, and suicidality","volume":"22","author":"Nicholas MN","year":"2017","journal-title":"Skin Therapy Lett"},{"key":"e_1_2_11_4_1","volume-title":"Psoriasis patient information sheet","author":"Skin Health Institute","year":"2020"},{"key":"e_1_2_11_5_1","volume-title":"PBS & RPBS items report July 2021 to June 2022","author":"Services Australia","year":"2022"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18851"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.11.041"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.11.042"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31773-8"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15750"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2021.1950600"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13611"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.208"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16436"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.22.003"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-021-00616-7"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-019-00334-1"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0129120"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2022.2909"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2022.151979"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdin.2021.06.004"}],"container-title":["Australasian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.14153","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T08:23:53Z","timestamp":1699518233000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajd.14153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,13]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1111\/ajd.14153"],"URL":"https:\/\/doi.org\/10.1111\/ajd.14153","archive":["Portico"],"relation":{},"ISSN":["0004-8380","1440-0960"],"issn-type":[{"value":"0004-8380","type":"print"},{"value":"1440-0960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,13]]},"assertion":[{"value":"2023-04-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}