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The final analysis enrolled 12 studies, including eight randomized controlled trial (RCT) (<jats:italic>n<\/jats:italic>\u2009=\u20095628 patients) and four observational cohort studies (OBSs) (<jats:italic>n<\/jats:italic>\u2009=\u2009393 patients). The meta\u2010analysis comprising nine studies (six RCTs and three OBSs) revealed a slight reduction in the levels of HOMA\u2010IR associated with the use of biological therapies in OBS (biological therapies vs. traditional therapies: WMD\u2009=\u2009\u22120.2, CI\u2009=\u2009\u22120.10 to 0.50, <jats:italic>p<\/jats:italic>\u2009=\u20090.02). Although a considerable number of studies were analysed, our review did not show a significant alteration in HOMA\u2010IR levels among patients treated with biological therapies such as IL\u201017 inhibitors and IL\u201012\/23 inhibitors at weeks 12\u201316 in RCTs. We also did not observe remarkable alterations in the fasting plasma glucose levels of patients in both OBS and RCT. Additional RCT on a larger scale and duration is required to provide more conclusive evidence regarding the effect of biological agents on glycogen metabolism in psoriasis.<\/jats:p>","DOI":"10.1111\/ajd.14168","type":"journal-article","created":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T07:04:50Z","timestamp":1698217490000},"page":"1-13","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of biological agents on glycogen metabolism in psoriasis patients: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8168-0862","authenticated-orcid":false,"given":"Ting","family":"He","sequence":"first","affiliation":[{"name":"Shanxi Medical University  Taiyuan Shanxi China"},{"name":"Department of Dermatology First Hospital of Shanxi Medical University  Taiyuan Shanxi 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