{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T06:48:29Z","timestamp":1768546109635,"version":"3.49.0"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T00:00:00Z","timestamp":1706054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Palmoplantar (PP) psoriasis is considered one of the most hard\u2010to\u2010treat areas with important impact on patients' quality of life, and few data are available about the efficacy of dimethylfumarate (DMF) on these areas. In our noninterventional multicentre retrospective cohort study of patients with PP psoriasis treated with DMF, effectiveness was evaluated as mean pp Psoriasis Area and Severity Index (ppPASI) reduction and as proportion of patients that reach ppPASI 75 at 4, 12, 24 and 48\u2009weeks. The reduction in ppPASI was 23.5% at w4, 49.7% at w12, 69.1% at w24 and 81.1% at w48. pp Investigator's Global Assessment (ppIGA) 0\/1 was reached by 5 patients (10.64%) at w4, 10 patients (23.8%) at w12, 11 patients (40.7%) at w24 and 12 patients (60%) at w48 confirming that DMF could represent an effective therapy in patients affected by PP psoriasis. Overall, the treatment was well tolerated although only 24 patients made it to 24\u2009weeks of therapy and 28 patients completed the observation period at 48\u2009weeks. None of the patients reported adverse events requiring discontinuation of the drug. However, this discontinuation rate is in line with clinical trials and real\u2010world evidence.<\/jats:p>","DOI":"10.1111\/ajd.14213","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T05:45:23Z","timestamp":1706161523000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Real\u2010life experience with dimethylfumarate in palmoplantar psoriasis: A multicentre retrospective Italian study"],"prefix":"10.1111","volume":"65","author":[{"given":"Caldarola","family":"Giacomo","sequence":"first","affiliation":[{"name":"Dermatology Unit, Department of Medical and Surgical Sciences A. Gemelli University Hospital Foundation\u2014IRCCS  Rome Italy"},{"name":"Dermatology Unit, Department of Medicine and Traslational Surgery Catholic University of Sacred Heart  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8301-9206","authenticated-orcid":false,"given":"Trovato","family":"Emanuele","sequence":"additional","affiliation":[{"name":"Unit of Dermatology, Department of Medical, Surgical and Neurological Sciences University of Siena  Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burlando","family":"Martina","sequence":"additional","affiliation":[{"name":"Department of Dermatology, DISSAL University of Genoa  Genoa Italy"},{"name":"IRCCS San Martino Hospital  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Capalbo","family":"Eugenio","sequence":"additional","affiliation":[{"name":"Unit of Dermatology, Department of Medical, Surgical and Neurological Sciences University of Siena  Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2274-1742","authenticated-orcid":false,"given":"Diotallevi","family":"Federico","sequence":"additional","affiliation":[{"name":"Dermatological Clinic, Department of Clinical and Molecular Sciences Polytechnic Marche University  Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lora","family":"Viviana","sequence":"additional","affiliation":[{"name":"Dermatology Unit San Gallicano Dermatological Institute, IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pinto Lorenzo","family":"Maria","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Medical and Surgical Sciences A. 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