{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T13:45:36Z","timestamp":1782740736759,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:00:00Z","timestamp":1707782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>Most studies about Papillon\u2013Lef\u00e8vre syndrome (PLS) are limited to case reports and patients of the same nationality. This study aimed to determine the self\u2010reported prevalence of signs, symptoms and treatment effectiveness in PLS patients from five Latin American countries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An online survey was conducted among adult and paediatric patients from Mexico, Argentina, Colombia and Brazil. Data were collected using multiple\u2010choice, open\u2010ended and image\u2010chooser questions on demographics, signs and symptoms, perceived treatment effectiveness and quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventeen patients (10 males and 7 females) aged 4\u201347\u2009years were surveyed. All had palmoplantar hyperkeratosis. Other affected sites were the feet and hand dorsum (82.35%), Achilles tendon (88.24%), forearms (58.82%), legs (29.41%) and glutes (23.53%). They frequently presented hyperhidrosis and nail pitting. Four had a history of delayed umbilical cord separation. All used topical treatments, with moderate effectiveness; half used oral retinoids, perceived as highly effective. Most reported decreased quality of life and walking difficulties.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The study's results align with prior research on PLS, but reveal new insights, including the impact on patients' quality of life and a history of delayed umbilical cord separation. These findings warrant consideration in future research and patient care.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.14219","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T05:34:02Z","timestamp":1707888842000},"page":"305-310","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Self\u2010reported clinical features and treatment effectiveness of Papillon\u2013Lef\u00e8vre syndrome patients from five Latin American countries: A cross\u2010sectional online survey study"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5747-5483","authenticated-orcid":false,"given":"Daniela","family":"Alfaro\u2010Sep\u00falveda","sequence":"first","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Universidad de Los Andes  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00eda Parra","family":"Salinas","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1032-9347","authenticated-orcid":false,"given":"Fernando","family":"Valenzuela","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Universidad de Chile  Santiago Chile"},{"name":"Department of Dermatology Cl\u00ednica Universidad de los Andes  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen Gloria","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Cl\u00ednica MEDS  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4097-7598","authenticated-orcid":false,"given":"Valentina","family":"Burckhardt\u2010Bravo","sequence":"additional","affiliation":[{"name":"Faculty of Medicine 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