{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T12:33:59Z","timestamp":1784032439420,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:00:00Z","timestamp":1709078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Numerous inflammatory skin diseases are associated with the gut microbiota. Studies of the association between gut microbiota and inflammatory skin diseases have yielded conflicting results owing to confounding factors, and the causal relationship between them remains undetermined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two\u2010sample Mendelian randomization (MR) was used to examine the association between gut microbiota and four common inflammatory skin diseases: acne, psoriasis, urticaria and atopic dermatitis. The summary statistics of the gut microbiota from the largest available genome\u2010wide association study meta\u2010analysis (<jats:italic>n<\/jats:italic>\u2009=\u200913,266) conducted by the MiBioGen consortium along with the summary statistics of the four diseases were obtained from the FinnGen consortium. Causal relationships were assessed using the inverse variance weighted (IVW), weighted median, MR\u2010Egger and maximum likelihood methods, and several sensitivity analyses were performed to ensure the accuracy of the results. Finally, reverse and multivariable MR analyses were performed to verify the robustness of the results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found causal associations of <jats:italic>Bacteroidaceae<\/jats:italic> [odds ratio (OR), 2.25; 95% confidence interval (CI), 1.48\u20133.42; <jats:italic>p<\/jats:italic><jats:sub>ivw<\/jats:sub>\u2009=\u20090.0001], <jats:italic>Allisonella<\/jats:italic> (OR, 1.42; 95% CI, 1.18\u20131.70; <jats:italic>p<\/jats:italic><jats:sub>ivw<\/jats:sub>\u2009=\u20090.0002) and <jats:italic>Bacteroides<\/jats:italic> (OR, 2.25; 95% CI, 1.48\u20133.42; <jats:italic>p<\/jats:italic><jats:sub>ivw<\/jats:sub>\u2009=\u20090.0001) with acne, the <jats:italic>Eubacterium fissicatena<\/jats:italic> group with psoriasis (OR, 1.22; 95% CI, 1.10\u20131.35; <jats:italic>p<\/jats:italic><jats:sub>ivw<\/jats:sub>\u2009=\u20090.0002) and <jats:italic>Intestinibacter<\/jats:italic> with urticaria (OR, 1.28; 95% CI, 1.13\u20131.45; <jats:italic>p<\/jats:italic><jats:sub>ivw<\/jats:sub>\u2009=\u20090.0001). These results were corrected for a false discovery rate. Sensitivity analyses were performed to validate the robustness of the associations and reverse MR confirmed that the results were not influenced by the reverse effect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study revealed that some gut microbiota are risk factors for inflammatory skin diseases, providing new information on potential therapeutic targets. Additionally, a possible association with the gut\u2013skin axis was confirmed. Further research is required to elucidate the mechanisms underlying these relationships.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.14231","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T05:19:20Z","timestamp":1709183960000},"page":"319-327","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Investigating causal relationships between the gut microbiota and inflammatory skin diseases: A Mendelian randomization study"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6074-4743","authenticated-orcid":false,"given":"Yunfan","family":"Gu","sequence":"first","affiliation":[{"name":"First Clinical College Hubei University of Chinese Medicine  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Zhao","sequence":"additional","affiliation":[{"name":"First Clinical College Hubei University of Chinese Medicine  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3891-7790","authenticated-orcid":false,"given":"Xianyu","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei China"},{"name":"First Clinical College Hubei University of Chinese Medicine  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2009.92"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1223813"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15913"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.10.037"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281\u2010009\u20100174\u20103"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2014.5585"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2013.834874"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555\u20102968"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17931"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201022125\u2010y"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.12.025"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010020\u201000763\u20101"},{"key":"e_1_2_11_14_1","doi-asserted-by":"crossref","unstructured":"KurkiMI KarjalainenJ PaltaP Sipil\u00e4TP KristianssonK DonnerK et\u00a0al.FinnGen: Unique genetic insights from combining isolated population and national health register data. 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