{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T13:59:32Z","timestamp":1781013572414,"version":"3.54.1"},"reference-count":4,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T00:00:00Z","timestamp":1709510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We present a palmoplantar pustulosis case partially resistant to systemic IL\u201017A inhibitor (ixekizumab) treatment, and then receiving a local injection of 0.1\u2009mL micro\u2010dose (1\u2009mg) IL\u201023 inhibitor (guselkumab) every 4\u2009weeks for four times. The paradoxical lesion disappeared rapidly following local injection and there was no recurrence after 8\u2009weeks of drug withdrawal. This is the first clinical report on the treatment of palmoplantar pustulosis by local injection of micro\u2010dose guselkumab.<\/jats:p>","DOI":"10.1111\/ajd.14244","type":"journal-article","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T05:35:24Z","timestamp":1709616924000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Local injection of micro\u2010dose guselkumab for palmoplantar pustulosis after partial failure of systemic ixekizumab treatment"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6854-1530","authenticated-orcid":false,"given":"Chaojing","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Dermatology First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyue","family":"Diao","sequence":"additional","affiliation":[{"name":"Department of Dermatology First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyun","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Dermatology First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6510-1051","authenticated-orcid":false,"given":"ZhiQiang","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Dermatology First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,4]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.14933"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2023.109694"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2020.03.003"},{"key":"e_1_2_2_5_1","first-page":"1485","article-title":"Pathogenesis of paradoxical reactions associated with targeted biologic agents for inflammatory skin diseases","volume":"10","author":"Miyagawa F","year":"2022","journal-title":"Biomedicine"}],"container-title":["Australasian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.14244","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T05:58:43Z","timestamp":1715925523000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajd.14244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,4]]},"references-count":4,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/ajd.14244"],"URL":"https:\/\/doi.org\/10.1111\/ajd.14244","archive":["Portico"],"relation":{},"ISSN":["0004-8380","1440-0960"],"issn-type":[{"value":"0004-8380","type":"print"},{"value":"1440-0960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,4]]},"assertion":[{"value":"2024-01-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}