{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:36:31Z","timestamp":1747182991618,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T00:00:00Z","timestamp":1712188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>Although excision of melanocytic nevi with high\u2010grade dysplasia is recommended by the World Health Organization (WHO), clinical studies investigating the approach based on the grading dysplasia of melanocytic lesions with peripheral globules (PGs) are lacking. We investigated the grades of dysplasia and their distinguishable dermoscopic and clinical features to provide accurate data for managing these lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively classified histologically confirmed melanocytic lesions with PGs according to the 2018 WHO Classification of Skin Tumours criteria in a university hospital in Turkey. Dermoscopic features, lesions, and patient characteristics were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010six lesions of 56 patients were included. After classification, 9.1% (<jats:italic>n<\/jats:italic>: 6) of lesions were melanomas, 39.4% (<jats:italic>n<\/jats:italic>: 26) were high\u2010grade dysplastic nevi, and 50% (<jats:italic>n<\/jats:italic>: 33) were low\u2010grade dysplastic nevi (<jats:italic>n<\/jats:italic>: 33, 50%). There was one nevus with no dysplasia (<jats:italic>n<\/jats:italic>: 1, 1.5%). Univariate analysis revealed that \u226531\u2009years of age, irregular shape of peripheral globules, black colour, total colour count, and maximum diameter of the lesion were associated with high\u2010grade dysplasia and melanoma. In the multivariate analyses, \u226531\u2009years of age (OR\u2009=\u20093.80, 95% CI, 1.17\u201312.37), irregular shape of peripheral globules (OR\u2009=\u20093.90, 95% CI, 1.15\u201313.2), and total colour count (OR\u2009=\u20093.21, 95% CI, 1.2\u20138.5) were significant predictive factors for the lesions with high\u2010grade dysplasia and melanomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>To avoid the underdiagnosis of both melanomas and high\u2010grade dysplastic nevi with PGs, the irregular shape of peripheral globules and multiple colours after the third decade may be useful in making an excision decision. The risk increases every 1\u2010year increase in age. Excision is suggested for all melanocytic lesions with PGs for patients 60\u2009years or older because of the high risk of melanoma and melanocytic nevus with high\u2010grade dysplasia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.14261","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T11:55:25Z","timestamp":1712231725000},"page":"358-368","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Can we manage the melanocytic lesions with peripheral globules according to the grade of dysplasia?"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1767-4960","authenticated-orcid":false,"given":"Ceylan","family":"Avc\u0131","sequence":"first","affiliation":[{"name":"Department of Dermatology Faculty of Medicine, Dokuz Eylul University  \u0130zmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6903-9227","authenticated-orcid":false,"given":"G\u00fclfem","family":"Ak\u0131n","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine, Dokuz Eylul University  \u0130zmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2520-2664","authenticated-orcid":false,"given":"Banu","family":"Lebe","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine, Dokuz Eylul University  \u0130zmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1412-7921","authenticated-orcid":false,"given":"Mustafa Turhan","family":"\u015eahin","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine, Manisa Celal Bayar University  Manisa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2927-9052","authenticated-orcid":false,"given":"Emel","family":"Fetil","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine, Dokuz Eylul University  \u0130zmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2010.10.003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2009.06.005"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2015.2231"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.149"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12464"},{"issue":"4","key":"e_1_2_8_7_1","first-page":"467","article-title":"Enlarging melanocytic lesions with peripheral globular pattern: a dermoscopic and confocal microscopy study","volume":"156","author":"Carbone A","year":"2021","journal-title":"Ital J Dermatol Venerol"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.08.107"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17239"},{"key":"e_1_2_8_10_1","first-page":"66","volume-title":"WHO classification of skin tumors","author":"Elder E","year":"2018"},{"issue":"4","key":"e_1_2_8_11_1","first-page":"156","article-title":"Clinical, dermoscopic and histological assessment of melanocytic lesions: a comparative study of the accuracy of the diagnostic methods","volume":"25","author":"Kalloniati E","year":"2021","journal-title":"Hippokratia"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.3.282"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2017.06.009"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1993.56"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.06.149"},{"key":"e_1_2_8_16_1","first-page":"82","volume-title":"WHO classification of skin tumors","author":"Elder E","year":"2018"},{"key":"e_1_2_8_17_1","article-title":"Pathologists' diagnosis of invasive melanoma and melanocytic proliferations: observer accuracy and reproducibility study","volume":"358","author":"Elmore JG","year":"2017","journal-title":"BMJ"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2009.285"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2013.06.010"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16674"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2022.04.031"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17035"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1502583"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17105"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07466.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07466.x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15809"},{"key":"e_1_2_8_28_1","doi-asserted-by":"crossref","unstructured":"StarkMS TanJM TomL JagirdarK LambieD SchaiderH et\u00a0al.Whole\u2010exome sequencing of acquired nevi identifies mechanisms for development and maintenance of benign neoplasms.2018;138(9):1636\u20131644.","DOI":"10.1016\/j.jid.2018.02.012"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.4045\/tidsskr.22.0204"}],"container-title":["Australasian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.14261","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T06:42:44Z","timestamp":1717656164000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajd.14261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,4]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/ajd.14261"],"URL":"https:\/\/doi.org\/10.1111\/ajd.14261","archive":["Portico"],"relation":{},"ISSN":["0004-8380","1440-0960"],"issn-type":[{"type":"print","value":"0004-8380"},{"type":"electronic","value":"1440-0960"}],"subject":[],"published":{"date-parts":[[2024,4,4]]},"assertion":[{"value":"2023-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}