{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T20:38:38Z","timestamp":1788813518218,"version":"build-2803163510"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T00:00:00Z","timestamp":1712534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>The evaluation of the efficacy and safety of new molecules for atopic dermatitis (AD) in real clinical practice is very important to obtain information that clinical trials (EECC) lack. The pattern of AD in the head and neck (H&amp;N) continues to be a challenge in treatment today, despite the new molecules, and real\u2010life data on the use of tralokinumab is still missing. This is the first daily practice study of tralokinumab treatment in patients with H&amp;N AD pattern. The objective is to evaluate the efficacy and safety of tralokinumab in the short term (16\u2009weeks) in patients with AD with H&amp;N pattern, for the first time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multicentre prospective observational study was conducted, including patients with moderate\u2010severe AD and H&amp;N pattern who started tralokinumab treatment in four hospitals in Andalusia. Values of severity and quality of life scales, as well as patient\u2010reported outcomes (PROs), were collected at baseline and at Weeks 4 and 16. Safety events were also recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve patients were included. An improvement was observed in all efficacy and quality of life parameters evaluated at 16\u2009weeks with respect to the baseline. No serious adverse events were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In real clinical practice, tralokinumab is demonstrated to be an effective and safe treatment for patients with AD and H&amp;N pattern at short term.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.14264","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T11:24:04Z","timestamp":1712575444000},"page":"260-265","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Efficacy and safety of tralokinumab in the treatment of head and neck pattern atopic dermatitis: A multicentre study of 12 patients"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5454-3671","authenticated-orcid":false,"given":"Francisco Jos\u00e9","family":"Navarro\u2010Trivi\u00f1o","sequence":"first","affiliation":[{"name":"Department of Contact Eczema and Immunoallergic Diseases, Dermatology Department Hospital Universitario San Cecilio  Granada Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria de Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Salazar\u2010Nievas","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Virgen de las Nieves  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Luis","family":"Sanz\u2010Cabanillas","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Reina Sof\u00eda  C\u00f3rdoba Spain"},{"name":"Instituto Maimonides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba  C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5542-5274","authenticated-orcid":false,"given":"Cintia","family":"Arjona\u2010Aguilera","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Poniente en El Ejido  Almer\u00eda Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ced\/llad153"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19108"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.14305"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/derm.2023.0030"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18753"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ced\/llad038"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-023-01258-7"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2022.2153578"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19091"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S382424"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.01.012"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.13678"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2022.02.018"}],"container-title":["Australasian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.14264","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T05:58:30Z","timestamp":1715925510000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajd.14264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,8]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/ajd.14264"],"URL":"https:\/\/doi.org\/10.1111\/ajd.14264","archive":["Portico"],"relation":{},"ISSN":["0004-8380","1440-0960"],"issn-type":[{"value":"0004-8380","type":"print"},{"value":"1440-0960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,8]]},"assertion":[{"value":"2023-06-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}