{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T14:12:30Z","timestamp":1780927950580,"version":"3.54.1"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,5]],"date-time":"2024-05-05T00:00:00Z","timestamp":1714867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>In the last 10\u2009years methylisothiazolinone (MI) emerged as a global cause of preservative\u2010related ACD. New Zealand has liberal regulations for the MI concentration limit in cosmetic products compared to Europe and Australia. The aim of this study was to evaluate the prevalence of MI sensitisation in New Zealand, explore sources of MI exposure and make recommendations on New Zealand regulations for MI use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included data from patients who underwent patch testing with MI from 2008 to 2021 in a tertiary hospital dermatology clinic and a private dermatology clinic in Auckland, New Zealand. Patient baseline characteristics were recorded along with results of patch testing. Sources of MI exposure were identified from medical records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over the study period, 1049 patch tests were performed in 1044 patients. MI was only tested as a stand\u2010alone allergen from 2015; positive reactions to MI increased from 5.3% in 2015 to a peak of 11.9% in 2017 and then decreased to 6.4% in 2021. The most common source of MI exposure was shampoo or conditioner (27.7% of all relevant reactions) followed by occupational exposures to paints, biocides or glue (19.1%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both sensitisation and ACD to MI appear to be decreasing, likely secondary to changes in product compounding due to stricter concentration limits internationally. We recommend New Zealand adopt lower MI concentration limits for cosmetics to match the limits of Australia and Europe.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.14301","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T01:28:16Z","timestamp":1714958896000},"page":"423-427","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Methylisothiazolinone sensitisation in New Zealand is decreasing"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9576-7898","authenticated-orcid":false,"given":"Hyun Kyoung","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Medicine, Health New Zealand Te Whatu Ora Waitemata  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4501-2211","authenticated-orcid":false,"given":"Harriet","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Health New Zealand Te Whatu Ora Auckland  Auckland New Zealand"},{"name":"Faculty of Medical and Health Sciences University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2022.5991"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10523.x"},{"key":"e_1_2_8_4_1","unstructured":"Scientific Committee on Consumer Safety.Opinion on methylisothiazolinone (P94) submission II (sensitisation only). [Internet]. Available from:https:\/\/ec.europa.eu\/health\/scientific_committees\/consumer_safety\/docs\/sccs_o_145.pdf. Accessed December 10 2023"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0b013e31827edc73"},{"key":"e_1_2_8_6_1","unstructured":"Safety assessment of methylisothiazolinone and methylchlorothiazolinone as used in cosmetics 2019 [Internet]. Cosmetic Ingredient Review Expert Panel; Available from:https:\/\/www.cir\u2010safety.org\/sites\/default\/files\/MI_MCI.pdf. Accessed December 10 2023"},{"issue":"4","key":"e_1_2_8_7_1","first-page":"201","article-title":"Occupational contact allergy and dermatitis from methylisothiazolinone after contact with wallcovering glue and after a chemical burn from a biocide","volume":"15","author":"Isaksson M","year":"2004","journal-title":"Dermatitis"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01754.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13025"},{"key":"e_1_2_8_10_1","unstructured":"Commission Regulation (EU) 2016\/1198 of 22 July 2016 [Internet]. Available from:https:\/\/eur\u2010lex.europa.eu\/legal\u2010content\/EN\/TXT\/PDF\/?uri=CELEX:32016R1198. Accessed December 10 2023"},{"key":"e_1_2_8_11_1","unstructured":"Commission Regulation (EU) 2017\/1224 of 6 July 2017 [Internet]. Available from:https:\/\/eur\u2010lex.europa.eu\/legal\u2010content\/EN\/TXT\/PDF\/?uri=CELEX:32017R1224&rid=1. Accessed December 10 2023"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1091581819838792"},{"key":"e_1_2_8_13_1","unstructured":"2.6 methylisothiazolinone [Internet]. Therapeutic Goods Administration (TGA). Available from:https:\/\/www.tga.gov.au\/resources\/publication\/scheduling\u2010decisions\u2010interim\/scheduling\u2010delegates\u2010interim\u2010decisions\u2010and\u2010invitation\u2010further\u2010comment\u2010accsacms\u2010march\u2010and\u2010july\u20102017\/26\u2010methylisothiazolinone. Accessed December 10 2023"},{"key":"e_1_2_8_14_1","unstructured":"Environmental Protection Agency.Cosmetic products group standard 2019 [Internet]. Available from:https:\/\/www.epa.govt.nz\/assets\/RecordsAPI\/Cosmetic\u2010Products\u2010Group\u2010Standard\u2010Schedules\u20104\u20108\u2010HSR002552.pdf. Accessed November 10 2023"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12432"},{"key":"e_1_2_8_16_1","unstructured":"June 2018 changes to the cosmetic ingredient hotlist. Available from:https:\/\/www.canada.ca\/en\/health\u2010canada\/services\/consumer\u2010product\u2010safety\/cosmetics\/cosmetic\u2010ingredient\u2010hotlist\u2010prohibited\u2010restricted\u2010ingredients\/changes.html. Accessed November 10 2023"},{"key":"e_1_2_8_17_1","unstructured":"Personal email communication with the New Zealand EPA regulation body dated 7th December 2023."},{"key":"e_1_2_8_18_1","unstructured":"Creating beauty from New Zealand: Supporting investment in the emerging natural or bio\u2010based cosmetics platform. Available from:https:\/\/www.mbie.govt.nz\/assets\/creating\u2010beauty\u2010from\u2010new\u2010zealand.pdf. Accessed December 10 2023"},{"key":"e_1_2_8_19_1","unstructured":"CIRS.New cosmetic ingredients approved from 2004 to 1 May 2021. Available from:https:\/\/www.cirs\u2010group.com\/en\/cosmetics\/the\u2010spring\u2010of\u2010new\u2010cosmetic\u2010ingredients\u2010filing\u2010in\u2010china. Accessed December 10 2023"},{"key":"e_1_2_8_20_1","unstructured":"Ministry of Health Labor and Welfare Notification No.331 of 2000. Standards for Cosmetics. Available from:https:\/\/www.mhlw.go.jp\/english\/dl\/cosmetics.pdf. Accessed December 10 2023"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13237"}],"container-title":["Australasian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.14301","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T10:39:08Z","timestamp":1755859148000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajd.14301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,5]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/ajd.14301"],"URL":"https:\/\/doi.org\/10.1111\/ajd.14301","archive":["Portico"],"relation":{},"ISSN":["0004-8380","1440-0960"],"issn-type":[{"value":"0004-8380","type":"print"},{"value":"1440-0960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,5]]},"assertion":[{"value":"2024-03-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}