{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:42:41Z","timestamp":1790959361891,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is a long\u2010standing debate if finasteride, a medication used to treat benign prostatic hyperplasia (BPH) and androgenetic alopecia (AGA), can cause psychiatric side effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The goal of this large\u2010scale population\u2010based study was to determine whether finasteride therapy for BPH and AGA is associated with the emergence of mental health conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This observational case\u2013control study compared the data from patients with BPH who received finasteride 5\u2009mg daily and patients with AGA who received finasteride 1\u2009mg daily with age\u2010 and gender\u2010matched controls. The incidence of psychological health outcomes such as depression, anxiety, neuroses, bipolar disorder, schizophrenia, psychoses and alcohol abuse within 2\u2009years of the initiation of finasteride therapy has been evaluated and compared between the finasteride groups and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The BPH group included 307 men with a mean age of 61.5 (\u00b117.4) years and 1218 controls. Mental health outcomes recorded in 2.3% of the patients, with no significant increase in rate when compared to controls. The AGA group consisted of 23,227 men with a mean age of 31.4 (\u00b110.3) years and 39,444 controls. One percent of AGA patients developed psychiatric disorders. In comparison to controls, patients with AGA had higher rates of anxiety and depression (0.6% vs. 0.4%, <jats:italic>p<\/jats:italic>\u2009=\u20090.04, and 0.5% vs. 0.4%, <jats:italic>p<\/jats:italic>\u2009=\u20090.007, respectively). In multivariate regression models, finasteride was found as one of the risk factors for anxiety (OR 1.449, <jats:italic>p<\/jats:italic>\u2009=\u20090.002) and depression (OR 1.439, <jats:italic>p<\/jats:italic>\u2009=\u20090.003) when stratified to age, sector, socioeconomic status and comorbidities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>According to our research, finasteride users had a very low rate of adverse mental health effects, with no increase in psychological sequelae in BPH patients and a slight increase in anxiety and depression in AGA patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.14359","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T05:53:35Z","timestamp":1723614815000},"page":"621-629","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The risk of psychiatric disorders in finasteride users with benign prostatic hyperplasia and androgenetic alopecia: A population\u2010based case\u2013control study"],"prefix":"10.1111","volume":"65","author":[{"given":"Anna","family":"Lyakhovitsky","sequence":"first","affiliation":[{"name":"Department of Dermatology Sheba Medical Center  Ramat\u2010Gan Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boaz","family":"Amichai","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Department of Dermatology Meir Medical Center  Kfar Saba Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1518-6875","authenticated-orcid":false,"given":"Eran","family":"Galili","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sheba Medical Center  Ramat\u2010Gan Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv 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