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In randomised controlled trials (RCTs) for apremilast no new cases of active tuberculosis (TB) were identified, thus, screening for latent TB infection (LTBI) is not currently recommended prior to apremilast initiation. We describe a case of <jats:italic>M.tuberculosis<\/jats:italic> reactivation shortly after commencement of apremilast for psoriasis. We are recommending clinicians perform LTBI risk assessment in all patients, and appropriate LTBI screening in select populations prior to apremilast initiation.<\/jats:p>","DOI":"10.1111\/ajd.14364","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T09:56:43Z","timestamp":1726048603000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Tuberculosis reactivation following apremilast therapy for psoriasis: Time to consider routine <scp>TB<\/scp> screening?"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2748-3383","authenticated-orcid":false,"given":"Lucinda","family":"Adams","sequence":"first","affiliation":[{"name":"Department of Dermatology Royal Darwin Hospital  Darwin Northern Territory Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma L.","family":"Smith","sequence":"additional","affiliation":[{"name":"Tuberculosis Unit, Centre of Disease Control, NT Health  Darwin Northern Territory Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dev","family":"Tilakaratne","sequence":"additional","affiliation":[{"name":"Department of Dermatology Royal Darwin Hospital  Darwin Northern Territory Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicki","family":"Krause","sequence":"additional","affiliation":[{"name":"Tuberculosis Unit, Centre of Disease Control, NT Health  Darwin Northern Territory Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr2.11156"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2014.05.014"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.01.052"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14015"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab199"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3410\/M1-30"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00028510"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(22)00359-7"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.33321\/cdi.2020.44.88"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.21.0111"},{"issue":"7","key":"e_1_2_6_12_1","first-page":"489","article-title":"Tuberculosis testing","volume":"41","author":"Coulter C","year":"2012","journal-title":"Aust Fam Physician"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanwpc.2021.100229"}],"container-title":["Australasian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.14364","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T12:23:04Z","timestamp":1736770984000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajd.14364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,11]]},"references-count":12,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1111\/ajd.14364"],"URL":"https:\/\/doi.org\/10.1111\/ajd.14364","archive":["Portico"],"relation":{},"ISSN":["0004-8380","1440-0960"],"issn-type":[{"value":"0004-8380","type":"print"},{"value":"1440-0960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,11]]},"assertion":[{"value":"2024-04-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}