{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T05:56:08Z","timestamp":1773899768777,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T00:00:00Z","timestamp":1730246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>Surgical deroofing is an essential part of ongoing management of Hidradenitis Suppurativa, including persistent lesions non\u2010responsive to medical therapy. The variables associated with delayed wound healing after surgical deroofing are contradictory within the literature due to the inclusion of heterogeneous surgical intervention methods. We aimed to assess the predictors of time to wound healing after surgical deroofing in HS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who underwent in\u2010office surgical deroofing between 2020 and 2024 at a single tertiary HS referral centre were included in analysis. Demographic, disease and blood variables were collected as per standard of care. Statistical analysis was performed using univariate correlation, with multiple regression performed to explore the interactions between variables and identify variables predictive of time to wound healing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 270 individuals were included in the analysis. The median time to wound healing was 9.6\u2009weeks with a range from 4 to 22\u2009weeks. Kaplan\u2013Meier curves demonstrated significant differences with the log rank test when comparing biologic use versus no use, normal versus abnormal CRP and normal versus abnormal haemoglobin. Cox regression analysis identified biologic use with a significant hazard ratio compared to no biologic therapy (HR\u2009=\u20092.512, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) along with baseline CRP (HR\u2009=\u20090.968, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and baseline haemoglobin (HR\u2009=\u20091.052, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Time to wound healing after in\u2010office deroofing can be decreased with prior biologic therapy and markers of systemic inflammation in blood are also significantly associated with delays in healing. This correlates well with the existing literature promoting concurrent medical and surgical therapy to improve patient outcomes in HS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.14375","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T09:59:41Z","timestamp":1730282381000},"page":"636-641","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Predictors of wound healing after surgical deroofing in Hidradenitis Suppurativa"],"prefix":"10.1111","volume":"65","author":[{"given":"James","family":"Pham","sequence":"first","affiliation":[{"name":"Laboratory of Translational Cutaneous Medicine Ingham Institute for Applied Medical Research  Liverpool, Sydney New South Wales Australia"},{"name":"Department of Dermatology Liverpool Hospital  Sydney New South Wales Australia"},{"name":"School of Clinical Medicine University of New South Wales  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tara","family":"Sholji","sequence":"additional","affiliation":[{"name":"Department of Dermatology Liverpool Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Guttman","sequence":"additional","affiliation":[{"name":"Department of Dermatology Liverpool Hospital  Sydney New South Wales Australia"},{"name":"School of Clinical Medicine University of New South Wales  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Allan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Liverpool Hospital  Sydney New South Wales Australia"},{"name":"School of Clinical Medicine University of New South Wales  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John W.","family":"Frew","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Cutaneous Medicine Ingham Institute for Applied Medical Research  Liverpool, Sydney New South Wales Australia"},{"name":"Department of Dermatology Liverpool Hospital  Sydney New South Wales Australia"},{"name":"School of Clinical Medicine University of New South Wales  Sydney New South Wales Australia"},{"name":"The Skin Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.16146"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13877"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2021.3655"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.12.018"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.13600"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13798"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.04.034"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljad388"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13887"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0000000000002105"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.03.090"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2021.4741"}],"container-title":["Australasian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.14375","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T12:23:36Z","timestamp":1736771016000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajd.14375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,30]]},"references-count":12,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1111\/ajd.14375"],"URL":"https:\/\/doi.org\/10.1111\/ajd.14375","archive":["Portico"],"relation":{},"ISSN":["0004-8380","1440-0960"],"issn-type":[{"value":"0004-8380","type":"print"},{"value":"1440-0960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,30]]},"assertion":[{"value":"2024-06-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}