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Although there are hundreds of reported cases of mBCCs, a dearth of evidence exists of mBCCs in patients with Gorlin syndrome\u2014an autosomal dominant genetic disorder. The purpose of this article was to present the first and largest case series of patients with mBCC in Gorlin. A literature review (LR) compares our data with the existing evidence base to underscore the importance of early surveillance, diagnosis and surgical intervention of suspicious lesions as distant metastases significantly reduce survival rates.<\/jats:p>","DOI":"10.1111\/ajd.14401","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T10:01:54Z","timestamp":1733997714000},"page":"36-39","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Metastatic basal cell carcinomas in Gorlin syndrome\u2014A case series and literature review"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8310-5750","authenticated-orcid":false,"given":"Usamah M.","family":"Afzal","sequence":"first","affiliation":[{"name":"Harrogate and District Foundation Trust  Harrogate UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal R.","family":"Ali","sequence":"additional","affiliation":[{"name":"University of Central Lancashire  Preston UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deemesh","family":"Oudit","sequence":"additional","affiliation":[{"name":"The Christie NHS Foundation Trust  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana","family":"Totorean","sequence":"additional","affiliation":[{"name":"The Christie NHS Foundation Trust  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gareth","family":"Evans","sequence":"additional","affiliation":[{"name":"St Marys Regional Genetics Centre  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"Lear","sequence":"additional","affiliation":[{"name":"MAHSC The Centre for Dermatology Research University of Manchester  Manchester UK"},{"name":"National Institutes of Health Biomedical Research Center Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.73.863.538"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(91)70108-E"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33139"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-3-32"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820115)49:2<350::AID-CNCR2820490223>3.0.CO;2-Y"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(18)30114-1"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91810-4"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195107)4:4<866::AID-CNCR2820040424>3.0.CO;2-F"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800512"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2013.12.013"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.25251\/skin.6.6.1"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.28080"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.2340\/actadv.v102.980"}],"container-title":["Australasian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.14401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T16:53:01Z","timestamp":1739465581000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajd.14401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,12]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/ajd.14401"],"URL":"https:\/\/doi.org\/10.1111\/ajd.14401","archive":["Portico"],"relation":{},"ISSN":["0004-8380","1440-0960"],"issn-type":[{"value":"0004-8380","type":"print"},{"value":"1440-0960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,12]]},"assertion":[{"value":"2024-08-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}