{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:42:14Z","timestamp":1790667734586,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Acne vulgaris is a common inflammatory condition that is often treated by dermatologists with isotretinoin. Isotretinoin has a number of effects on inflammatory pathways, with clear efficacy in managing acne vulgaris. There are also well\u2010documented side effects of isotretinoin, including hyperlipidemia; however, the overall cardiovascular risk is unclear. This systematic review revealed low evidence for major adverse cardiovascular events associated with the use of isotretinoin in acne patients. Despite this low evidence, rare events may be associated and should still be considered when using isotretinoin in acne patients.<\/jats:p>","DOI":"10.1111\/ajd.14424","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T04:28:47Z","timestamp":1739248127000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Systematic Review of Rare Major Adverse Cardiovascular Events Associated With the Treatment of Acne With Isotretinoin"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1212-269X","authenticated-orcid":false,"given":"Timothy L.","family":"Cowan","sequence":"first","affiliation":[{"name":"The Canberra Hospital  Garran Australian Capital Territory Australia"},{"name":"School of Medicine and Psychology Australian National University  Garran Australian Capital Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7186-082X","authenticated-orcid":false,"given":"Madeleine","family":"Stark","sequence":"additional","affiliation":[{"name":"The Canberra Hospital  Garran Australian Capital Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0121-1322","authenticated-orcid":false,"given":"Simona","family":"Sarmiento","sequence":"additional","affiliation":[{"name":"The Canberra Hospital  Garran Australian Capital Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8522-7751","authenticated-orcid":false,"given":"Andrew","family":"Miller","sequence":"additional","affiliation":[{"name":"The Canberra Hospital  Garran Australian Capital Territory Australia"},{"name":"School of Medicine and Psychology Australian National University  Garran Australian Capital Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(11)60321\u20108"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403\u2010019\u201001908\u2010x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15043"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.17633"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1983.01650360033009"},{"key":"e_1_2_12_7_1","doi-asserted-by":"crossref","unstructured":"E. L. C.Aromataris K.Porritt B.Pilla andZ.Jordan eds. \u201cJBI Manual for Evidence Synthesis 2024 \u201d2024 https:\/\/synthesismanual.jbi.global.","DOI":"10.46658\/JBIMES-24-01"},{"key":"e_1_2_12_8_1","unstructured":"G. A.Wells D.O'Connell J.Peterson V.Welch M.Losos andP.Tugwell \u201cThe Newcastle\u2010Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta\u2010Analyses \u201d2000 https:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp2024."},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_12_11_1","unstructured":"C. T.MA \u201cSystematic Review of Cardiovascular Risk in Acne Patients Taking Isotretinoin \u201dPROSPERO 2023 CRD42023435263 2023 https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?ID=CRD42023435263."},{"issue":"2","key":"e_1_2_12_12_1","first-page":"487","article-title":"Isotretinion Induced Pulmonary Thromboembolism","volume":"6","author":"Agrawal S.","year":"2015","journal-title":"Research Journal of Pharmaceutical, Biological and Chemical Sciences"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.5543\/tkda.2018.67055"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806\u20104841.20165138"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2019.158479"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100625.2009.00924.x"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701155"},{"key":"e_1_2_12_18_1","article-title":"Development of Granulomatosis With Polyangiitis During Systemic Retinoid Therapy, Case Report","volume":"197","author":"Assuncao G.","year":"2018","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102133.2003.05209_1.x"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2014.01.381"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540\u20108159.2005.09365.x"},{"issue":"4","key":"e_1_2_12_22_1","first-page":"387","article-title":"Isotretinoin (13\u2010Cis\u2010Retinoic Acid)\u2010Associated Premature Ventricular Contractions","volume":"51","author":"Kilic E.","year":"2009","journal-title":"Turkish Journal of Pediatrics"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752\u20101947\u20103\u201058"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1K028"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.11.169"},{"issue":"4","key":"e_1_2_12_26_1","article-title":"Isotretinoin Induced Granulomatosis With Polyangitis","volume":"13","author":"Malone C.","year":"2018","journal-title":"Journal of Hospital Medicine"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2015.08.1418"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13091543"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccm.0000727356.49761.e0"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(89)91820\u20105"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440\u20100960.2010.00657"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257\u2010020\u201000568\u20102"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartjsupp\/suac121.753"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm\u201020\u20104212"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403\u2010022\u201002508\u2010y"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610\u20100387.2010.07344.x"},{"issue":"5","key":"e_1_2_12_37_1","first-page":"559","article-title":"The Role of Transcription Factor FoxO1 in the Pathogenesis of Acne Vulgaris and the Mode of Isotretinoin Action","volume":"145","author":"Melnik B. C.","year":"2010","journal-title":"Giornale Italiano di Dermatologia e Venereologia"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12222600"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/120347540000400205"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13307"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20104362.1997.00306.x"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1999.00544.x"},{"issue":"7","key":"e_1_2_12_43_1","first-page":"710","article-title":"Isotretinoin Does Not Prolong QT Intervals and QT Dispersion in Patients With Severe Acne: A Surprising Finding for a Drug With Numerous Side Effects","volume":"10","author":"Dursun R.","year":"2011","journal-title":"Journal of Drugs in Dermatology"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20186721"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1159\/000248880"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13931"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.10800"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.122.060860"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2011.05.048"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.Hyp.0000146400.57221.74"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20104632.2008.03341.x"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.5114\/ada.2018.76848"}],"container-title":["Australasian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.14424","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T05:26:52Z","timestamp":1746768412000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajd.14424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,10]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/ajd.14424"],"URL":"https:\/\/doi.org\/10.1111\/ajd.14424","archive":["Portico"],"relation":{},"ISSN":["0004-8380","1440-0960"],"issn-type":[{"value":"0004-8380","type":"print"},{"value":"1440-0960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,10]]},"assertion":[{"value":"2024-10-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}