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This case series describes six patients, who developed acneiform eruptions following the initiation of deucravacitinib for chronic plaque psoriasis. Through this case series, we aim to shed further light into the clinical characteristics and potential risk factors for this side effect. Contrary to clinical trial data, we demonstrate high cessation rates of deucravacitinib following the development of acneiform eruption, due to the significant burden on quality of life. We highlight the need to identify risk factors to improve patient selection and allow adequate counselling or prophylactic treatments for these acneiform eruptions.<\/jats:p>","DOI":"10.1111\/ajd.14425","type":"journal-article","created":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T03:29:48Z","timestamp":1738380588000},"page":"157-161","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Acneiform Eruption Secondary to Deucravacitinib: A Case Series and Review of the Literature"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6955-5483","authenticated-orcid":false,"given":"Vanessa","family":"Tran","sequence":"first","affiliation":[{"name":"Department of Dermatology Royal Melbourne Hospital  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celestine","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Dermatology Royal Melbourne Hospital  Parkville Victoria Australia"},{"name":"Chroma Dermatology Pigment and Skin of Colour Centre  Melbourne Victoria Australia"},{"name":"Department of Dermatology Monash Health  Clayton Victoria Australia"},{"name":"Faculty of Medicine, Dentistry and Health Sciences The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senhong","family":"Lee","sequence":"additional","affiliation":[{"name":"Chroma Dermatology Pigment and Skin of Colour Centre  Melbourne Victoria Australia"},{"name":"Department of Dermatology Monash Health  Clayton Victoria Australia"},{"name":"Skin Health Institute  Carlton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Chroma Dermatology Pigment and Skin of Colour Centre  Melbourne Victoria Australia"},{"name":"Faculty of Medicine, Dentistry and Health Sciences The University of Melbourne  Melbourne Victoria Australia"},{"name":"Department of Dermatology Royal Children's Hospital  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2022.08.061"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaw1736"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2023.3830"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2022.07.002"},{"issue":"8","key":"e_1_2_8_6_1","first-page":"978","article-title":"Psychological Sequelae of Acne Vulgaris: Results of a Qualitative Study","volume":"52","author":"Magin P.","year":"2006","journal-title":"Canadian Family Physician"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2022.09.029"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2024.2371045"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ced\/llae495"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14563"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-024-03314-4"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.7087"},{"key":"e_1_2_8_13_1","volume-title":"Taylor and Kelly's Dermatology for Skin of Color","author":"Taylor S. 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