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The term \u2018CARD14\u2010associated papulosquamous eruption (CAPE)\u2019 is used to describe individuals presenting with symptoms of both conditions. This study aimed to diagnose two cases of CAPE and explore the pathogenic mechanisms, including inflammatory trends and differential features. Whole\u2010exome sequencing and Sanger sequencing identified a novel variant, c.2768T&gt;C and a recurrent variant, c.467T&gt;C, in <jats:italic>CARD14<\/jats:italic> in two unrelated individuals, both exhibiting incomplete penetrance. Both of patients exhibited increased IL\u201017A in skin lesions, but not in serum, potentially explaining the reported cases with low response rate to secukinumab. One patient also exhibited increased IL\u201023A in serum. Additionally, the epidermis of lesions showed aberrant late differentiation and active NF\u2010\u03baB signalling.<\/jats:p>","DOI":"10.1111\/ajd.14455","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T10:27:21Z","timestamp":1741948041000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Similar Molecular Features in Two Cases of <scp>CARD14<\/scp>\u2010Associated Papulosquamous Eruption"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5298-3171","authenticated-orcid":false,"given":"Yumeng","family":"Wang","sequence":"first","affiliation":[{"name":"Dermatology Center Xinhua Hospital, Shanghai Jiaotong University School of Medicine  Shanghai China"},{"name":"Department of Dermatology Xinhua Hospital, Shanghai Jiaotong University School of Medicine  Shanghai China"},{"name":"Institute of Dermatology Shanghai Jiaotong University School of 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