{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T10:35:22Z","timestamp":1772102122239,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Adalimumab, a tumour necrosis factor\u2010alpha inhibitor, has demonstrated efficacy in managing hidradenitis suppurativa (HS) at the standard dose of 40\u2009mg weekly; however, many patients do not achieve adequate clinical response with this regimen. This systematic review aimed to evaluate the efficacy and safety of 80\u2009mg weekly adalimumab in HS management. Four studies, with a total of 67 patients, were reviewed. The studies reported improvements in HS disease severity and quality of life measures with the use of high\u2010dose adalimumab. Adverse events were infrequent and generally mild, with no severe adverse events reported. The findings suggest a favourable response to high\u2010dose adalimumab for patients with severe or refractory HS; however, definitive conclusions are limited by the scarcity and low quality of the available data. Further high\u2010quality research with standardised outcome measures and longer follow\u2010up are needed to validate the role of dose intensification in HS management.<\/jats:p>","DOI":"10.1111\/ajd.14465","type":"journal-article","created":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T17:16:36Z","timestamp":1742922996000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of High Dose Adalimumab for the Management of Hidradenitis Suppurativa: A Systematic Review"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8944-4497","authenticated-orcid":false,"given":"Leah","family":"Jones","sequence":"first","affiliation":[{"name":"Health New Zealand Counties Manukau  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jihee","family":"Sun","sequence":"additional","affiliation":[{"name":"Health New Zealand Counties Manukau  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harriet","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Auckland City Hospital  Auckland New Zealand"},{"name":"University of Auckland  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504370"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000026190"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.4081\/dr.2018.7859"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.15691"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000437077"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.14388"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.20525"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.6868"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2024.07.066"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2022.06.239"}],"container-title":["Australasian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.14465","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T10:13:32Z","timestamp":1754907212000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajd.14465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,25]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/ajd.14465"],"URL":"https:\/\/doi.org\/10.1111\/ajd.14465","archive":["Portico"],"relation":{},"ISSN":["0004-8380","1440-0960"],"issn-type":[{"value":"0004-8380","type":"print"},{"value":"1440-0960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,25]]},"assertion":[{"value":"2025-02-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}