{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:43:29Z","timestamp":1787013809470,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Current first\u2010line topical treatments for atopic dermatitis (AD) are often limited by concerns related to age, systemic absorption, especially when applied to large body surface areas or under maximal usage conditions and undesirable adverse events (AEs), highlighting the need for alternative therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a systematic review and meta\u2010analysis of seven randomised controlled trials (RCT) comparing\u00a0topical aryl hydrocarbon receptor agonists (TAHRA), including tapinarof and benvitimod cream, to vehicle at different concentrations and application frequencies in patients with AD, which evaluated outcomes such as Investigator Global Assessment (IGA) scores\/Validated Investigator's Global Assessment (vIGA), the Eczema Area and Severity Index (EASI\u201075), change from baseline in body surface area (BSA) and pruritus score (PS) and safety profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1631 patients, 1086 received TAHRA, while 545 received vehicle. Overall, TAHRA led to a significant improvement in the IGA\/vIGA scores (RR 2.38; 95% CI 1.68 to 3.37;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.00001), EASI\u201075 (RR 2.94; 95% CI 2.07 to 4.17;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.00001). Similar findings were observed for mean change from baseline in BSA% (MD \u22126.08; 95% CI \u22128.00 to \u22124.16;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.00001), and PS (Std MD \u22120.90; 95% CI \u22121.41 to \u22120.39;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0006). The incidence of AEs was significantly higher in the TAHRA group (RR 1.48; 95% CI 1.19 to 1.85;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0005). We found no significant difference in the incidence of serious adverse events (SAEs) (RR 1.51; 95% CI 0.34 to 6.64;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.59). Treatment\u2010emergent adverse events (TEAEs), such as folliculitis, were more frequent in the TAHRA group (RR 8.06; 95% CI 2.75 to 23.60;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings support the efficacy of TAHRA among different metrics with minimal and tolerable AEs\u00a0and its use as a valuable new non\u2010steroidal option for the treatment of AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ajd.14485","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T12:00:44Z","timestamp":1744027244000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Safety and Efficacy of Non\u2010Steroidal Topical Aryl Hydrocarbon Receptor Agonists for the Treatment of Atopic Dermatitis: A Systematic Review and Meta\u2010Analysis of Randomised Controlled Trials"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6737-9305","authenticated-orcid":false,"given":"Martin","family":"Cevallos\u2010Cueva","sequence":"first","affiliation":[{"name":"School of Medicine Universidad Central del Ecuador  Quito Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1948-3029","authenticated-orcid":false,"given":"Carlos Alberto Monteiro Leit\u00e3o","family":"Neto","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Pavia  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2496-6119","authenticated-orcid":false,"given":"Devanie","family":"Martani","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Universitas Tarumanagara Jakarta  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7918-0107","authenticated-orcid":false,"given":"Laura","family":"Ghanem","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences Lebanese University  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9417-3451","authenticated-orcid":false,"given":"Camila Almeida","family":"Sardinha","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences, Faculty of Minas FAMINAS\u2010 BH  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1481-5166","authenticated-orcid":false,"given":"Daniela Luc\u00eda","family":"Mendoza\u2010Mill\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Dermatology Beth Israel Deaconess Medical Center  Boston Massachusetts 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