{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T15:07:27Z","timestamp":1784646447643,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Extramammary Paget's disease (EMPD) is a neoplastic condition primarily in the anogenital region. A subset of cases exhibits HER2 expression, generally associated with poor prognosis. This paper aimed to systematically explore the potential correlation between HER2 expression, clinicopathological features and prognosis in EMPD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic search (1990\u20132023) was conducted via BVS, Embase, Google Scholar, PubMed, Scopus and Web of Science. A meta\u2010analysis with odds ratios (ORs) and confidence intervals (CIs) was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 954 patients from 16 studies were included. The median age at diagnosis was 70.3\u2009years, with the majority being men (71.8%). The penoscrotal area was the most common site of presentation. HER2 positivity was 25.6%, and the HER2\u2010low proportion was 38.5%. Positive HER2 expression was correlated with EMPD dermal invasion (OR\u2009=\u20094.01, 95% CI: 2.11\u20137.62) and the presence of lymph node metastasis (OR\u2009=\u20093.84, 95% CI: 1.59\u20139.30), but not with the presence of secondary malignancies or the female gender. Gene expression among patients with IHC 2+ and 3+ was correlated with tumour dermal invasion (pooled OR\u2009=\u20096.43, 95% CI: 1.23\u201333.57). No correlation was found between HER2\u2010low expression and dermal invasion, lymph node metastasis or the presence of secondary primary malignancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HER2 was expressed in a significant proportion in EMPD with significant correlations, suggesting its potential role as a prognostic biomarker.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.14490","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T08:35:36Z","timestamp":1744706136000},"page":"279-288","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>HER2<\/scp> Expression and Its Correlation With Clinicopathological Features and Prognosis in Extramammary Paget's Disease: A Systematic Review 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