{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T18:32:39Z","timestamp":1755801159818,"version":"3.44.0"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>New\u2010onset lichen planus (LP) development following COVID\u201019 infection\/vaccination is reported. Since case series cannot be used to study exposure\u2013outcome associations, we designed this matched case\u2013control study to investigate whether COVID\u201019\u2010related events and de novo LP are associated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with histologically confirmed LP, newly diagnosed at the National Research Center of Dermato\u2010Venereology of Moscow (September 2020\u2013December 2022), were considered. Sex\/age\/ethnicity\u2010matched controls attending the same Center in the same period for consultations on conditions unrelated to LP were selected. Cases\/controls with known LP trigger factors were excluded. COVID\u201019\u2010related events were: symptomatic COVID\u201019 (PCR\u2010confirmed), and COVID\u201019 vaccination (viral vector vaccine) occurred \u2264 1\u2009month before the visit at the Center. The association between COVID\u201019\u2010related events and LP was assessed with conditional (Mantel\u2013Haenszel method) and unconditional (logistic regression analysis adjusted for sex, age, and smoking) analyses. Subgroup analysis, with COVID\u201019 infection and vaccination treated separately, and sensitivity analysis on another group of patients with suspected LP, not confirmed histologically, were also made.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010five case\u2013control pairs were considered. Mean age (51\u2009years), sex (56.4% females) and ethnicity (100% whites) distributions were the same in both groups. Conditional and unconditional odds ratios resulted 7.50 (95% Confidence Interval \u2013<jats:styled-content style=\"fixed-case\">95CI<\/jats:styled-content>, 1.72\u201332.80), 4.45 (<jats:styled-content style=\"fixed-case\">95CI<\/jats:styled-content>, 1.63\u201312.15), respectively (<jats:italic>p<\/jats:italic>\u2009&lt; 0.05). Subgroup analysis confirmed the association between symptomatic infection and <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>, while sensitivity analysis corroborated the results of the primary analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This observational study, reporting a strong significant association between COVID\u201019 infection\/vaccination and de\u2010novo LP, suggests that COVID\u201019\u2010related events, especially infection, could act as LP trigger factors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.14522","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T07:43:02Z","timestamp":1746430982000},"page":"289-295","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lichen Planus Following <scp>COVID<\/scp>\u201019 Infection and Vaccination. 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