{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T08:59:30Z","timestamp":1773046770687,"version":"3.50.1"},"reference-count":6,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Tebentafusp, a bispecific TCR\u2010anti\u2010CD3 fusion protein targeting gp100\u2010HLA\u2010A02:01 complexes, is approved for the treatment of unresectable\/metastatic uveal melanoma (MUM). In this retrospective, single\u2010centre series, five HLA\u2010A02:01\u2010positive patients received tebentafusp. Four developed cutaneous toxicity (80%) within hours of the first infusion, primarily symmetric erythematoedematous truncal plaques. Other findings included acral xerosis\/exfoliation and vitiligo\u2010like lesions. Histology revealed spongiosis with subcorneal pustules, which have not been previously reported. No patients discontinued treatment due to skin toxicity and lesions resolved in a mean of 14.5\u2009days. One patient died due to disease progression. Dermatological events are likely to be on\u2010target effects of gp100+ melanocyte targeting and correlate with CD8+ T cell infiltration. Dermatological involvement is common and manageable, highlighting the need for early dermatological input in patients receiving tebentafusp. Emerging data suggest a possible association between rash and response, which warrants further investigation.<\/jats:p>","DOI":"10.1111\/ajd.70004","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T09:53:27Z","timestamp":1763718807000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dermatological Toxicities of Tebentafusp, a New Bispecific Drug: Case Series and Literature Review"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6730-6723","authenticated-orcid":false,"given":"Miguel","family":"Mansilla\u2010Polo","sequence":"first","affiliation":[{"name":"Dermatology Department Hospital Universitario y Polit\u00e9cnico La Fe  Valencia Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria La Fe (IIS La Fe)  Valencia 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Department Hospital Universitario y Polit\u00e9cnico La Fe  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"D\u00edaz\u2010Beveridge","sequence":"additional","affiliation":[{"name":"Oncology Department Hospital Universitario y Polit\u00e9cnico La Fe  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Botella\u2010Estrada","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospital Universitario y Polit\u00e9cnico La Fe  Valencia Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria La Fe (IIS La Fe)  Valencia Spain"},{"name":"Faculty of Medicine Universidad de Valencia  Valencia 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