{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T12:56:54Z","timestamp":1773233814813,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although adalimumab has shown strong efficacy and safety in clinical trials, real\u2010world evidence in Australian patients with moderate\u2010to\u2010severe chronic plaque psoriasis is limited. This study assessed adalimumab efficacy and drug survival in routine clinical practice, comparing outcomes with the Phase 3 REVEAL trial and its open\u2010label extension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were extracted from the Australasian Psoriasis Registry for adults meeting Pharmaceutical Benefits Scheme criteria to be prescribed adalimumab for chronic plaque psoriasis. Baseline demographics, Psoriasis Area and Severity Index (PASI) scores and treatment history between June 2006 and March 2022 were analysed. Drug survival was evaluated using Kaplan\u2013Meier and Cox regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 306 patients were included; 59.8% had prior biologic exposure compared to 12.8% in REVEAL. The mean baseline PASI was 24.1 and at 3\u2009months, 63.5% achieved PASI75 while 33.6% achieved PASI90. PASI90 responses remained stable through 3\u2009years and exceeded REVEAL extension rates beyond 18\u2009months. Median drug survival was 27.9\u2009months; survival was 97.7%, 78.6%, 63.7% and 51.0% at 3, 9, 15 and 27\u2009months, respectively. Male sex and achieving PASI \u2264\u20092 predicted longer drug survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In Australian real\u2010world practice, adalimumab demonstrated sustained effectiveness and drug survival in patients with chronic plaque psoriasis comparable to RCTs, despite higher baseline disease severity and greater prior biologic exposure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ajd.70024","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T04:51:52Z","timestamp":1770094312000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010World Efficacy and Drug Survival of Adalimumab in Australian Patients With Psoriasis"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0509-0944","authenticated-orcid":false,"given":"N.","family":"Punchihewa","sequence":"first","affiliation":[{"name":"Skin Health Institute  Carlton Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. K.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Skin Health Institute  Carlton Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5701-7570","authenticated-orcid":false,"given":"J. 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