{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T08:07:25Z","timestamp":1778832445057,"version":"3.51.4"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background\/Objectives<\/jats:title>\n The Royal Brisbane & Women's Hospital (RBWH) in Queensland, Australia provides definitive care for all diagnosed adult patients with SJS\/TEN within its catchment. In this retrospective cohort study, we identified all SJS\/TEN cases at RBWH over a 10\u2010year period. We assessed disease incidence and the relationship of 3 variables (disease severity, time taken to admission to the definitive tertiary centre and systemic immunosuppressive treatment) to the outcome of mortality.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Patients were identified via ICU MetaVision dermatology entries, discharge coding and manual admission recording. Age, gender, culprit drug, time to definitive tertiary centre admission, total body surface area (TBSA), SCORTEN, complications, systemic therapy utilisation and mortality were recorded. Relationships between variables were analysed using Spearman's Rank correlations and logistic regression.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Fifty\u2010two cases over 10\u2009years met inclusion criteria (37 TEN, 8 SJS\/TEN and 7 SJS). Mortality (9.6%; 5 deaths) was low compared to published rates. Multivariate regression analysis revealed a significant relationship between increased SCORTEN and mortality as expected. There was no significant relationship between systemic treatment and mortality or between \u2018days to definitive care\u2019 and mortality. Modelling accounted for 44% of variance in mortality.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n SJS\/TEN incidence matched published rates. Severity of SJS\/TEN and mortality were correlated. Neither systemic immune suppression nor time taken to be admitted to the definitive tertiary centre correlated with mortality. Expert multidisciplinary care in the RBWH ICU and Burns Unit is likely to contribute to the excellent mortality outcomes found. Limitations of the study included its retrospective cohort design, that it was performed in a single centre, and the relatively small sample size leading to statistically insignificant findings. Our results should bolster growing data to improve understanding of this rare but serious condition.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ajd.70076","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:03:00Z","timestamp":1772967780000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A 10\u2010Year Retrospective Cohort Study of Stevens\u2013Johnson Syndrome and Toxic Epidermal Necrolysis at the Royal Brisbane and Women's Hospital"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7280-3484","authenticated-orcid":false,"given":"Thomas","family":"Pagliaro","sequence":"first","affiliation":[{"name":"Royal Brisbane & Women's Hospital Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Butler","sequence":"additional","affiliation":[{"name":"Royal Brisbane & Women's Hospital Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Godbolt","sequence":"additional","affiliation":[{"name":"Royal Brisbane & Women's Hospital Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Yong\u2010Gee","sequence":"additional","affiliation":[{"name":"Royal Brisbane & Women's Hospital Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Francis","sequence":"additional","affiliation":[{"name":"Royal Brisbane & Women's Hospital Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Robertson","sequence":"additional","affiliation":[{"name":"Royal Brisbane & Women's Hospital Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"issue":"5","key":"e_1_2_11_2_1","first-page":"7","article-title":"Toxic Epidermal Necrolysis: A Review of Past and Present Therapeutic Approaches","volume":"27","author":"Singh N.","year":"2022","journal-title":"Skin Therapy Letter"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257\u2010024\u201000889\u20106"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.13903"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2019.1568380"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.24748.1"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57090895"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.6999"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14530"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016\u2010021\u201008859\u20100"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.64719\/pb.4398"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S491791"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523\u20101747.2000.00061.x"}],"container-title":["Australasian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.70076","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajd.70076","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.70076","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T07:13:19Z","timestamp":1778829199000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajd.70076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,24]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/ajd.70076"],"URL":"https:\/\/doi.org\/10.1111\/ajd.70076","archive":["Portico"],"relation":{},"ISSN":["0004-8380","1440-0960"],"issn-type":[{"value":"0004-8380","type":"print"},{"value":"1440-0960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,24]]},"assertion":[{"value":"2025-09-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}