{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T08:07:55Z","timestamp":1778832475886,"version":"3.51.4"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Stevens\u2013Johnson syndrome\/toxic epidermal necrolysis (SJS\/TEN) is a rare, severe skin reaction with high mortality, most often triggered by medications. Early identification of patients at risk is essential for guiding treatment. The SCORTEN score, comprising seven clinical and laboratory variables, is widely used to predict mortality but may have limitations across different populations. We conducted a systematic review and meta\u2010analysis to assess SCORTEN's predictive accuracy and identify additional blood biomarkers associated with mortality in SJS\/TEN. The primary aim was to evaluate the prognostic performance of individual SCORTEN parameters in adult SJS\/TEN patients. The secondary aim was to explore modified SCORTEN cut\u2010offs and identify additional laboratory biomarkers associated with mortality. We searched Medline, Embase and the Cochrane Library up to March 2024 for relevant studies. Eligible studies were assessed for quality and pooled analyses were conducted using a random\u2010effects model. A total of 45 studies with 3467 patients were included. All seven SCORTEN variables were significantly associated with in\u2010hospital mortality. Additionally, elevated serum creatinine, a marker of kidney function, was independently associated with increased risk of death. Other biomarkers showed potential, but data were insufficient for pooled analysis. Our results reinforce the value of SCORTEN and suggest serum creatinine may enhance risk prediction. Improved prognostication in SJS\/TEN could support earlier intervention and better use of critical care resources. Further research is needed to validate new biomarkers.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    PROSPERO registration number: CRD42022344691\n                  <\/jats:p>","DOI":"10.1111\/ajd.70082","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T10:13:03Z","timestamp":1772964783000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>SCORTEN<\/scp>\n                    and Novel Prognostic Markers in Stevens\u2013Johnson Syndrome\/Toxic Epidermal Necrolysis: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9848-1919","authenticated-orcid":false,"given":"Zhao Feng","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Dermatology The Alfred Hospital  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3265-2762","authenticated-orcid":false,"given":"Howard","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Monash Health  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence","family":"Lin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Nursing and Health Sciences Monash University  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ash","family":"Tyagi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Nursing and Health Sciences Monash University  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Sylivris","sequence":"additional","affiliation":[{"name":"The Royal Melbourne Hospital  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1262-6935","authenticated-orcid":false,"given":"Adithya","family":"Shastry","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Nursing and Health Sciences Monash University  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nidhin Sunil","family":"Kuruvilla","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Nursing and Health Sciences Monash University  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Gin","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Alfred Hospital  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher Y.","family":"Chew","sequence":"additional","affiliation":[{"name":"Skin Health Institute  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-015-0158-0"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1993.01680220104023"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1956.tb12766.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199411103311906"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.510"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00061.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2018.5605"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000354264"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700068"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0b013e31820aafbc"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2020.3654"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.05.022"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16137"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2016.5668"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.BCR.0000216532.71360.9B"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2021.5119"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04502.x"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.04.082"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11684-020-0817-2"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.05.047"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2017.09.015"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0203642"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083138"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-158-4-201302190-00009"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119558378"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijd.IJD_217_19"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.939210"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcs078"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700068"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0b013e31815f3865"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/jbcr\/irx016"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-017-0530-y"},{"key":"e_1_2_11_34_1","article-title":"Systemic Interventions for Treatment of Stevens\u2010Johnson Syndrome (SJS), Toxic Epidermal Necrolysis (TEN), and SJS\/TEN Overlap Syndrome","volume":"3","author":"Jacobsen A.","year":"2022","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.03.023"},{"key":"e_1_2_11_36_1","article-title":"Are Multimorbidities Underestimated in Scoring Systems of Stevens\u2010Johnson Syndrome and Toxic Epidermal Necrolysis Like in SCORTEN?","volume":"12","author":"Von Wild T.","year":"2012","journal-title":"Eplasty"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2023.07.001"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90297-2"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1159\/000195632"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.03.030"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1935.15.4.597"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2017.05.014"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1159\/000475802"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15968"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.16661"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.4997\/jrcpe.2020.409"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15490"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burnso.2022.03.006"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16891"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2021.11.004"}],"container-title":["Australasian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.70082","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajd.70082","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.70082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T07:13:35Z","timestamp":1778829215000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajd.70082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,6]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/ajd.70082"],"URL":"https:\/\/doi.org\/10.1111\/ajd.70082","archive":["Portico"],"relation":{},"ISSN":["0004-8380","1440-0960"],"issn-type":[{"value":"0004-8380","type":"print"},{"value":"1440-0960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,6]]},"assertion":[{"value":"2025-07-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}