{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T09:15:21Z","timestamp":1792746921238,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Biologic and small\u2010molecule therapies are increasingly used in dermatology for conditions such as psoriasis and atopic dermatitis. Live and live\u2010attenuated vaccines are traditionally avoided in patients receiving these agents due to concerns regarding vaccine\u2010strain infection. We conducted a systematic review to evaluate the safety of live and live\u2010attenuated vaccines in patients receiving biologic or small\u2010molecule therapies used in dermatologic practice. PubMed, Embase (Ovid) and the Cochrane Library were searched from January 2010 to February 2025 for human studies reporting safety or immunogenicity outcomes following live vaccine administration in patients receiving relevant therapies. Of 1104 records identified, nine studies met inclusion criteria, comprising one randomised controlled trial, three cohort studies, three retrospective case series, one cross\u2010sectional observational study and one case report. Vaccines evaluated included measles\u2010mumps\u2010rubella, measles\u2010mumps\u2010rubella\u2010varicella, varicella, live zoster and yellow fever vaccines. Across studies, no cases of vaccine\u2010strain infection or disseminated vaccine\u2010related disease were reported. Mild and self\u2010limiting post\u2010vaccination reactions were described in several cohorts. Where assessed, immunogenicity responses were generally preserved, although data were limited and inconsistently reported. Most included studies involved patients receiving biologic or small\u2010molecule monotherapy, though some cohorts permitted background conventional immunomodulatory therapy. The available evidence, although limited and predominantly observational, suggests that selected live and live\u2010attenuated vaccines may be administered without serious adverse outcomes in carefully chosen patients receiving biologic or small\u2010molecule therapies. Larger prospective studies are needed to better define safety and immunogenicity across newer targeted agents.<\/jats:p>","DOI":"10.1111\/ajd.70088","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T05:05:08Z","timestamp":1773810308000},"page":"259-269","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Safety of Live and Live\u2010Attenuated Vaccines in Patients Receiving Biologics and Small\u2010Molecule Therapies for Dermatologic Diseases: A Systematic Review"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1750-7934","authenticated-orcid":false,"given":"Alex Li","family":"Majri","sequence":"first","affiliation":[{"name":"Royal Perth Hospital  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Chan","sequence":"additional","affiliation":[{"name":"Sir Charles Gairdner Hospital  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.11.057"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.14156"},{"key":"e_1_2_13_4_1","unstructured":"\u201cVaccination for People Who Are Immunocompromised. The Australian Immunisation Handbook \u201d(2025) https:\/\/immunisationhandbook.health.gov.au\/contents\/vaccination\u2010for\u2010special\u2010risk\u2010groups\/vaccination\u2010for\u2010people\u2010who\u2010are\u2010immunocompromised."},{"key":"e_1_2_13_5_1","volume-title":"General Best Practices for Immunization","author":"CDC","year":"2025"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102019\u2010215882"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.46497\/ArchRheumatol.2021.8212"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.90a.23008"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/crgm\/6088333"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2024.05.014"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines9050487"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431\u2010021\u201003927\u20101"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3497"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.15518"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.15818"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.70033"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2020.01.037"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.7326\/M20\u20106928"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24010"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100042\u2010109871"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abd.2020.09.009"}],"container-title":["Australasian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.70088","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajd.70088","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.70088","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:33:44Z","timestamp":1787841224000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajd.70088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,17]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/ajd.70088"],"URL":"https:\/\/doi.org\/10.1111\/ajd.70088","archive":["Portico"],"relation":{},"ISSN":["0004-8380","1440-0960"],"issn-type":[{"value":"0004-8380","type":"print"},{"value":"1440-0960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,17]]},"assertion":[{"value":"2026-01-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}