{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:11:27Z","timestamp":1790993487629,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Topical ruxolitinib 1.5% cream is the first approved therapy for repigmentation in non\u2010segmental vitiligo. However, treatment response varies, and reliable predictors of efficacy remain undefined. This narrative review examined clinical trials and observational studies investigating factors associated with response to ruxolitinib cream. A comprehensive search of MEDLINE, Cochrane CENTRAL and\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                    (through June 2025) identified 14 eligible studies. Anatomical site was the most consistent predictor, with facial lesions showing the highest repigmentation rates and acral areas demonstrating poor response. Early clinical improvement was associated with better long\u2010term outcomes. Long\u2010term data indicated that repigmentation can persist after treatment discontinuation in a substantial proportion of patients. Demographic and disease\u2010related variables, including age, sex, disease duration and phototype, showed mixed results across studies. Adjunctive narrowband UVB improved repigmentation in initial non\u2010responders but provided limited benefit in early responders. Exploratory biomarker data suggested that Th2 cytokine profiles and reductions in CXCL10 levels may be linked to response, although these findings remain unvalidated. Overall, anatomical location and early clinical response appear to be the most reliable indicators of ruxolitinib efficacy. Further studies with standardized endpoints and predictive modelling are needed to guide individualized treatment strategies in vitiligo.\n                  <\/jats:p>","DOI":"10.1111\/ajd.70090","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T06:09:27Z","timestamp":1773727767000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Predictors of Response to Topical Ruxolitinib in Non\u2010segmental Vitiligo: A Narrative Review"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4374-802X","authenticated-orcid":false,"given":"Luca","family":"Bettolini","sequence":"first","affiliation":[{"name":"Dermatology Department University of Brescia, ASST Spedali Civili di Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0420-5009","authenticated-orcid":false,"given":"Vincenzo","family":"Maione","sequence":"additional","affiliation":[{"name":"Dermatology Department University of Brescia, ASST Spedali Civili di Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8231-2205","authenticated-orcid":false,"given":"Andrea","family":"Carugno","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery University of Insubria  Varese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7454-1999","authenticated-orcid":false,"given":"Zeno","family":"Fratton","sequence":"additional","affiliation":[{"name":"Department of Medicine, Institute of Dermatology University of Udine  Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7152-6136","authenticated-orcid":false,"given":"Enzo","family":"Errichetti","sequence":"additional","affiliation":[{"name":"Department of Medicine, Institute of Dermatology University of Udine  Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Crivellari","sequence":"additional","affiliation":[{"name":"Dermatology Department University of Brescia, ASST Spedali Civili di Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Cartocci","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Medical, Surgical and Neurological Sciences University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo Alberto","family":"Maronese","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Fondazione IRCCS ca' Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Venturini","sequence":"additional","affiliation":[{"name":"Dermatology Department University of Brescia, ASST Spedali Civili di Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Zerbinati","sequence":"additional","affiliation":[{"name":"Department of Medicine and Technology University of Insubria  Varese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5101-159X","authenticated-orcid":false,"given":"Mariateresa","family":"Rossi","sequence":"additional","affiliation":[{"name":"Dermatology Department University of Brescia, ASST Spedali Civili di Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2781-6909","authenticated-orcid":false,"given":"Stefano","family":"Bighetti","sequence":"additional","affiliation":[{"name":"Dermatology Department University of Brescia, ASST Spedali Civili di Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,16]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555\u2010025\u201001397\u2010z"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.02.049"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.02.023"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)30609\u20107"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.05.047"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2022.05.1093"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xjidi.2023.100230"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ski2.404"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2118828"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.20236"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555\u2010025\u201001381\u20107"},{"key":"e_1_2_13_13_1","unstructured":"\u201cA study to evaluate the mechanism of action of ruxolitinib cream in subjects with vitiligo (TRuE\u2010V MOA). NCT04896385 \u201dhttps:\/\/clinicaltrials.gov\/ct2\/show\/NCT04896385?cond=TRuE\u2010V+MOA&draw=2&rank=1."},{"key":"e_1_2_13_14_1","unstructured":"\u201cA Study to Evaluate the Safety and Efficacy of Ruxolitinib Cream With Phototherapy in Participants With Vitiligo. NCT05247489 \u201dhttps:\/\/clinicaltrials.gov\/study\/NCT05247489?cond=Vitiligo&intr=Ruxolitinib&page=1&rank=9."},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2025.04.041"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljaf143"},{"key":"e_1_2_13_17_1","unstructured":"\u201cAssess the Long Term Efficacy and Safety of Ruxolitinib Cream in Participants With Vitiligo. NCT04530344 \u201dhttps:\/\/clinicaltrials.gov\/study\/NCT04530344?cond=Vitiligo&intr=Ruxolitinib&page=1&rank=1."},{"key":"e_1_2_13_18_1","unstructured":"\u201cA Study to Evaluate the Safety and Efficacy of Ruxolitinib Cream in Pediatric Participants With Nonsegmental Vitiligo. NCT06548360 \u201dhttps:\/\/clinicaltrials.gov\/study\/NCT06548360?cond=Vitiligo&intr=Ruxolitinib&page=1&rank=7."},{"key":"e_1_2_13_19_1","unstructured":"\u201cA Study to Evaluate the Efficacy and Safety of Ruxolitinib Cream in Children (6 to <\u200912\u2009Years Old) With Nonsegmental Vitiligo NCT06804811 \u201dhttps:\/\/clinicaltrials.gov\/study\/NCT06804811?cond=Vitiligo&intr=Ruxolitinib&page=1&rank=6."},{"key":"e_1_2_13_20_1","unstructured":"\u201cTopical Ruxolitinib for Face and Neck Vitiligo of Adult Chinese Patients Refractory to Topical Tacrolimus (RCT). NCT06719024 \u201dhttps:\/\/clinicaltrials.gov\/study\/NCT06719024?cond=Vitiligo&intr=Ruxolitinib&page=1&rank=8."}],"container-title":["Australasian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.70090","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajd.70090","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.70090","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T06:36:13Z","timestamp":1780295773000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajd.70090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,16]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/ajd.70090"],"URL":"https:\/\/doi.org\/10.1111\/ajd.70090","archive":["Portico"],"relation":{},"ISSN":["0004-8380","1440-0960"],"issn-type":[{"value":"0004-8380","type":"print"},{"value":"1440-0960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,16]]},"assertion":[{"value":"2025-07-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}