{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T06:00:38Z","timestamp":1785132038236,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Epidermolysis bullosa (EB) is an inherited mechanobullous genodermatosis caused by a mutation in genes encoding proteins integral to skin integrity. Premature termination codon readthrough therapies, such as gentamicin, have promise in facilitating full\u2010length protein expression in patients with EB. We conducted a systematic review of the effectiveness and adverse effects of gentamicin for wound healing in EB. Six databases were searched to 01 September 2025 for clinical trials investigating gentamicin for EB. Risk of bias was assessed using the ROBINS\u2010I tool, and data were synthesised descriptively. This study was registered with PROSPERO (CRD42024496582). Five studies involving 24 patients with junctional EB or dystrophic EB were included; four were open\u2010label and one was double\u2010blinded. Nineteen of the 24 patients had a known nonsense mutation. Gentamicin was administered topically (two studies), intravenously (two studies) and both topically and intradermally (one study). Wound healing was heterogeneously measured across studies, with all but one showing improved outcomes. All patients demonstrated increased expression of glycoprotein or collagen in skin biopsy specimens after gentamicin treatment. No adverse events were noted. However, four of five studies were at serious risk of bias on ROBINS\u2010I, primarily owing to lack of blinding and absence of control groups, increasing the risk of bias for subjective outcomes such as wound healing. The available evidence suggests gentamicin may improve wound healing in EB caused by nonsense mutations, but the small number of heterogeneous studies precludes high\u2010level evidence. Larger, blinded, randomised trials are required to confirm efficacy and long\u2010term safety.<\/jats:p>","DOI":"10.1111\/ajd.70184","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T05:26:21Z","timestamp":1785129981000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Systematic Review of Topical and Systemic Gentamicin for Wound Healing in Patients With Junctional and Dystrophic Epidermolysis Bullosa"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9596-4499","authenticated-orcid":false,"given":"Kelvin","family":"Truong","sequence":"first","affiliation":[{"name":"Department of Dermatology Sydney Children's Hospital  Randwick New South Wales Australia"},{"name":"School of Clinical Medicine, Faculty of Medicine and Health UNSW Sydney  Kensington New South Wales Australia"},{"name":"Sydney Medical School, Faculty of Medicine and Health University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8579-7634","authenticated-orcid":false,"given":"Joseph","family":"Joseph","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sydney Children's Hospital  Randwick New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Poh","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Faculty of Medicine and Health UNSW Sydney  Kensington New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4466-6985","authenticated-orcid":false,"given":"Orli","family":"Wargon","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sydney Children's Hospital  Randwick New South Wales Australia"},{"name":"School of Clinical Medicine, Faculty of Medicine and Health UNSW Sydney  Kensington New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6011-9757","authenticated-orcid":false,"given":"Artiene","family":"Tatian","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sydney Children's Hospital  Randwick New South Wales Australia"},{"name":"School of Clinical Medicine, Faculty of Medicine and Health UNSW Sydney  Kensington New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17012"},{"key":"e_1_2_10_3_1","first-page":"41","article-title":"Recessive Dystrophic Epidermolysis Bullosa: A Review of Disease Pathogenesis and Update on Future Therapies","volume":"8","author":"Soro L.","year":"2015","journal-title":"Journal of Clinical and Aesthetic 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Y.Hou X.Tang et\u00a0al. \u201cNovel Readthrough Agent Suppresses Nonsense Mutations and Restores Functional Type VII Collagen and Laminin 332 in Epidermolysis Bullosa 2025\u201d.","DOI":"10.1016\/j.omtn.2024.102334"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells14151215"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2206663"}],"container-title":["Australasian Journal of 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