{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T06:45:23Z","timestamp":1785912323623,"version":"3.56.0"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Alopecia areata (AA) is a non\u2010scarring, immune\u2010mediated hair loss disorder with substantial psychosocial impact in children. Robust paediatric real\u2010world evidence regarding Janus kinase inhibitors (JAKi) for this disease is limited. In this study, we describe real\u2010world clinical outcomes and safety of JAKi for paediatric AA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective, observational multicentre study across 11 Spanish hospitals including patients aged 0\u201318\u2009years who initiated a first JAKi (baricitinib, tofacitinib, or ritlecitinib) in routine care. The primary outcome was Severity of Alopecia Tool (SALT)\u201050. Secondary outcomes included the absolute SALT trajectory, eyebrow\/eyelash responses, adverse events, and switching to a second JAKi.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty\u2010six patients were included (baricitinib 22\/46 [47.8%], tofacitinib 14\/46 [30.4%], ritlecitinib 10\/46 [21.7%]; mean age 11.3\u2009\u00b1\u20094.0\u2009years). Eight patients (21.6%) achieved SALT\u201050 at weeks 4\u20138, 21 patients (58.3%) at week 16, 20 patients (80.0%) at week 48, and 14 patients (82.4%) at week 72. Eyebrow and eyelash responses improved concordantly. At week 16, higher baseline SALT reduced the odds of response (\u03b2\u2009=\u2009\u22120.061, SE 0.029;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.034). Unadjusted response rates varied across drug groups; however, treatment allocation was non\u2010random, and groups were markedly imbalanced at baseline, so drug\u2010level comparisons are exploratory and likely confounded by indication. Response was lower in universalis (unadjusted\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008). Adverse events occurred in 16 of 46 patients (34.8%), mostly mild, with two patients (4.3%) discontinuing treatment. A second JAKi was used in seven patients (15.2%): Three complete, two partial, and two absent responses occurred post\u2010switch.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>In real\u2010world paediatric practice, we observed improvements in scalp, eyebrow, and eyelash involvement with JAKi use, with a generally favourable tolerability profile. Given the observational design, baseline imbalances, and missing data, causal inference and between\u2010drug comparisons are not supported.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ajd.70189","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:53:23Z","timestamp":1785909203000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010World Outcomes and Safety of\n                    <scp>JAK<\/scp>\n                    Inhibitors in Paediatric Alopecia Areata: A Retrospective Multicentre Study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6730-6723","authenticated-orcid":false,"given":"Miguel","family":"Mansilla\u2010Polo","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital Universitario Y Polit\u00e9cnico La Fe  Valencia Valencia Spain"},{"name":"Instituto De Investigaci\u00f3n Sanitaria (IIS) La Fe  Valencia Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0438-1184","authenticated-orcid":false,"given":"Aniza","family":"Giacaman","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Son Espases  Palma de Mallorca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6454-2971","authenticated-orcid":false,"given":"Carlos","family":"Abril\u2010P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Y Polit\u00e9cnico La Fe  Valencia Valencia Spain"},{"name":"Instituto De Investigaci\u00f3n Sanitaria (IIS) La Fe  Valencia Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7918-4733","authenticated-orcid":false,"given":"Daniel","family":"Mart\u00edn\u2010Torregrosa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Y Polit\u00e9cnico La Fe  Valencia Valencia Spain"},{"name":"Instituto De Investigaci\u00f3n Sanitaria (IIS) La Fe  Valencia Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Berbegal\u2010de","family":"Gracia","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Doctor Balmis  Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"D\u00edaz\u2010Corpas","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Doctor Peset  Valencia Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9242-8841","authenticated-orcid":false,"given":"Ainhoa","family":"Fern\u00e1ndez\u2010Arregui","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Cl\u00ednico Universitario De Valencia  Valencia Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2121-6727","authenticated-orcid":false,"given":"Javier","family":"Melgosa\u2010Ramos","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Llu\u00eds Alcany\u00eds De X\u00e0tiva  X\u00e0tiva Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5040-8483","authenticated-orcid":false,"given":"Alberto","family":"Soto\u2010Moreno","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Virgen De Las Nieves  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Ruiz\u2010Villanueva","sequence":"additional","affiliation":[{"name":"Department of Dermatology Complejo Asistencial Universitario De Salamanca  Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juncal","family":"Roca\u2010Gin\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General Universitario De Castell\u00f3n  Castell\u00f3n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Pitarch\u2010Bort","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General Universitario De Castell\u00f3n  Castell\u00f3n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9609-3701","authenticated-orcid":false,"given":"Altea","family":"Esteve\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General Universitario De Valencia  Valencia Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Mart\u00edn\u2010Santiago","sequence":"additional","affiliation":[{"name":"Department 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\u2010 Un Update on the Management of Alopecia Areata","volume":"2","author":"Pinto\u2010Pulido E. 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