{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T05:19:56Z","timestamp":1787980796523,"version":"build-2784847793"},"reference-count":10,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Beh\u00e7et's disease is a rare multisystem inflammatory disorder characterised by recurrent oral and genital ulceration with systemic involvement. Heterozygous mutations in NF\u2010\u03baB1 have been associated with Beh\u00e7et's\u2010like presentations. We present a woman with psoriasis, lichen sclerosus, non\u2010small\u2010cell lung cancer, anogenital ulcers and features of a Beh\u00e7et's\u2010like syndrome associated with a novel NF\u2010\u03baB1 mutation. She responded well to adalimumab after failed treatment with systemic and topical corticosteroids, antibiotics and colchicine.<\/jats:p>","DOI":"10.1111\/ajd.70202","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T05:02:32Z","timestamp":1787979752000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Beh\u00e7et's\u2010Like Syndrome Associated With Psoriasis, Lichen Sclerosus and Variant in\n                    <scp>NF<\/scp>\n                    \u2010\n                    <scp>\u03baB1<\/scp>"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9576-7898","authenticated-orcid":false,"given":"Hyun Kyoung","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Medicine Health New Zealand, Te Whatu Ora Waikato  Hamilton New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Corkill","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Health New Zealand, Te Whatu Ora Waitemata  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4501-2211","authenticated-orcid":false,"given":"Harriet","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Faculty of Medical and Health Sciences University of Auckland  Auckland New Zealand"},{"name":"Department of Dermatology Health New Zealand, Te Whatu Ora Te Toka Tumai  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"issue":"8697","key":"e_1_2_10_2_1","first-page":"1078","article-title":"Criteria for Diagnosis of Beh\u00e7et's Disease","volume":"335","author":"International Study Group for Beh\u00e7et's Disease","year":"1990","journal-title":"Lancet"},{"issue":"5","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","DOI":"10.1111\/sji.12973","article-title":"Beh\u00e7et Disease (BD) and BD\u2010Like Clinical Phenotypes: NF\u2010\u03baB Pathway in Mucosal Ulcerating Diseases","volume":"92","author":"Perazzio S. F.","year":"2020","journal-title":"Scandinavian Journal of Immunology"},{"issue":"3","key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.jaci.2016.10.054","article-title":"Damaging Heterozygous Mutations in NFKB1 Lead to Diverse Immunologic Phenotypes","volume":"140","author":"Kaustio M.","year":"2017","journal-title":"Journal of Allergy and Clinical Immunology"},{"issue":"11","key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1038\/s41598-021-81972-4","article-title":"Association of Beh\u00e7et Disease With Psoriasis and Psoriatic Arthritis","volume":"28","author":"Hahn H. J.","year":"2021","journal-title":"Scientific Reports"},{"issue":"44","key":"e_1_2_10_6_1","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000017735","article-title":"Risk of Malignancy in Behcet Disease","volume":"98","author":"Wang X.","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"e_1_2_10_7_1","unstructured":"NCBI \u201cVCV002172741.3\u2014ClinVar \u201d(2025) https:\/\/www.ncbi.nlm.nih.gov\/clinvar\/variation\/2172741\/."},{"issue":"3","key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1093\/bjd\/ljad421","article-title":"Role of the NLRP1 Inflammasome in Skin Cancer and Inflammatory Skin Diseases","volume":"190","author":"Calabrese L.","year":"2024","journal-title":"British Journal of Dermatology"},{"key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1111\/j.1365-2230.2008.02786.x","article-title":"The Functional Role of Nuclear Factor Kappa\u2010kappaB1 \u201094 Ins\/del ATTG Promotor Gene Polymorphism in Beh\u00e7et's Disease: An Exploratory Study","volume":"33","author":"Yalcin B.","year":"2008","journal-title":"Clinical and Experimental Dermatology"},{"key":"e_1_2_10_10_1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/sji.12251","article-title":"Association of NFKB1 and NFKBIA Polymorphisms in Relation to Susceptibility of Beh\u00e7et's Disease","volume":"81","author":"Yenmis G.","year":"2015","journal-title":"Scandinavian Journal of Immunology"},{"issue":"4","key":"e_1_2_10_11_1","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.jaci.2019.11.051","article-title":"Characterization of the Clinical and Immunologic Phenotype and Management of 157 Individuals With 56 Distinct Heterozygous NFKB1 Mutations","volume":"146","author":"Lorenzini T.","year":"2020","journal-title":"Journal of Allergy and Clinical Immunology"}],"container-title":["Australasian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.70202","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajd.70202","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.70202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T05:02:34Z","timestamp":1787979754000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajd.70202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,28]]},"references-count":10,"alternative-id":["10.1111\/ajd.70202"],"URL":"https:\/\/doi.org\/10.1111\/ajd.70202","archive":["Portico"],"relation":{},"ISSN":["0004-8380","1440-0960"],"issn-type":[{"value":"0004-8380","type":"print"},{"value":"1440-0960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,28]]},"assertion":[{"value":"2026-06-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"ajd.70202"}}