{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T05:18:30Z","timestamp":1788239910565,"version":"build-2803163510"},"reference-count":10,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI17\/02172"],"award-info":[{"award-number":["PI17\/02172"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI21\/01724"],"award-info":[{"award-number":["PI21\/01724"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["15826\/004"],"award-info":[{"award-number":["15826\/004"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["41163\/005"],"award-info":[{"award-number":["41163\/005"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PMP21\/00015"],"award-info":[{"award-number":["PMP21\/00015"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031478","name":"NextGenerationEU","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["2021\u2010SGR\u201001172"],"award-info":[{"award-number":["2021\u2010SGR\u201001172"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012818","name":"Comunidad de Madrid","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Primary cutaneous gamma\u2010delta T\u2010cell lymphoma (PCGDTCL) is a rare cytotoxic lymphoma with considerable clinicopathological heterogeneity. We report three patients with unusual presentations, including a TCR\u2010silent phenotype with spontaneous regression followed by rapid progression, a granulomatous variant with a prolonged indolent course, and a lupus panniculitis\u2010like form. Molecular studies demonstrated persistent clonal disease and identified recurrent alterations involving\n                    <jats:italic>TET2<\/jats:italic>\n                    ,\n                    <jats:italic>STAT3<\/jats:italic>\n                    ,\n                    <jats:italic>CDKN2A<\/jats:italic>\n                    ,\n                    <jats:italic>MAPK1<\/jats:italic>\n                    ,\n                    <jats:italic>PDCD1<\/jats:italic>\n                    and\n                    <jats:italic>TNFAIP3<\/jats:italic>\n                    , with acquisition of additional mutations during disease evolution. These cases expand the recognized spectrum of PCGDTCL and highlight the importance of integrating clinicopathological and molecular findings in diagnostically challenging presentations.\n                  <\/jats:p>","DOI":"10.1111\/ajd.70204","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T04:53:06Z","timestamp":1788238386000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary Cutaneous Gamma\u2010Delta T\u2010Cell Lymphoma With Unusual Clinicopathological Characteristics: A Study of Three Patients With Molecular Characterization"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5066-5014","authenticated-orcid":false,"given":"Luc\u00eda","family":"Prieto\u2010Torres","sequence":"first","affiliation":[{"name":"Dermatology Department Hospital Cl\u00ednico Universitario Lozano Blesa  Zaragoza Spain"},{"name":"Faculty of Medicine University of Zaragoza  Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5450-4146","authenticated-orcid":false,"given":"Rebeca","family":"Manso","sequence":"additional","affiliation":[{"name":"Pathology Department Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Universidad Aut\u00f3noma  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7070-0550","authenticated-orcid":false,"given":"Francisco Javier Diaz","family":"de la Pinta","sequence":"additional","affiliation":[{"name":"Pathology Department Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Universidad Aut\u00f3noma  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2078-8205","authenticated-orcid":false,"given":"Mar Garc\u00eda","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Zaragoza  Zaragoza Spain"},{"name":"Pathology Department Hospital Cl\u00ednico Universitario Lozano Blesa  Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Moreno","sequence":"additional","affiliation":[{"name":"Pathology Department Hospital Universitario Ram\u00f3n y Cajal  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6780-0390","authenticated-orcid":false,"given":"Maria Asunci\u00f3n Ballester","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospital Universitario Ram\u00f3n y Cajal  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4711-5142","authenticated-orcid":false,"given":"Angel Santos","family":"Briz","sequence":"additional","affiliation":[{"name":"Pathology Department Hospital Cl\u00ednico Universitario de Salamanca  Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"Rodr\u00edguez\u2010Peralto","sequence":"additional","affiliation":[{"name":"Pathology Department Hospital Universitario 12 de Octubre, I+12 Research Institute, Universidad Complutense  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Torre","family":"Castro","sequence":"additional","affiliation":[{"name":"Dermatology Department Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Universidad Aut\u00f3noma  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Cerroni","sequence":"additional","affiliation":[{"name":"Research Unit of Dermatopathology Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1347-3507","authenticated-orcid":false,"given":"Luis","family":"Requena","sequence":"additional","affiliation":[{"name":"Dermatology Department Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Universidad Aut\u00f3noma  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Socorro Mar\u00eda Rodr\u00edguez","family":"Pinilla","sequence":"additional","affiliation":[{"name":"Pathology Department Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Universidad Aut\u00f3noma  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1038\/s41467-020-15572-7","article-title":"Cellular Origins and Genetic Landscape of Cutaneous Gamma Delta T Cell Lymphomas","volume":"11","author":"Daniels J.","year":"2020","journal-title":"Nature Communications"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.clindermatol.2023.09.008","article-title":"Panniculitic Primary Cutaneous Gamma Delta T\u2010Cell Lymphoma With Concomitant Features of Autoimmune Disease Emphasizing a Pathophysiologic Continuum of Lupus Profundus With the Panniculitic T Cell Lymphomas","volume":"41","author":"Magro C. 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E.","year":"1999","journal-title":"Human Pathology"},{"key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s40164-021-00225-2","article-title":"Successful Salvage Therapy for Refractory Primary Cutaneous Gamma\u2010Delta T\u2010Cell Lymphoma With a Combination of Brentuximab Vedotin and Gemcitabine","volume":"10","author":"Voruz S.","year":"2021","journal-title":"Experimental Hematology & Oncology"},{"key":"e_1_2_11_7_1","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1097\/PAS.0b013e31822067d1","article-title":"Nonhepatosplenic \u03b3\u03b4 T\u2010Cell Lymphomas Represent a Spectrum of Aggressive Cytotoxic T\u2010Cell Lymphomas With a Mainly Extranodal Presentation","volume":"35","author":"Garcia\u2010Herrera A.","year":"2011","journal-title":"American Journal of Surgical Pathology"},{"key":"e_1_2_11_8_1","doi-asserted-by":"crossref","first-page":"e489","DOI":"10.3324\/haematol.2018.215327","article-title":"Clonal Sequence Tracking Reveals TET2\u2010Mutated Extranodal NK\/T\u2010Cell Lymphoma Disseminated Independent of Epstein Barr Virus","volume":"104","author":"Yuan C. T.","year":"2019","journal-title":"Haematologica"},{"key":"e_1_2_11_9_1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3390\/dermatopathology8020027","article-title":"A Previously Unrecognized Granulomatous Variant of Gamma\u2010Delta T\u2010Cell Lymphoma","volume":"8","author":"Pukhalskaya T.","year":"2021","journal-title":"Dermatopathology"},{"key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1097\/DAD.0b013e3181a84f32","article-title":"Subcutaneous Panniculitis\u2010Like T\u2010Cell Lymphoma With Overlapping Clinicopathologic Features of Lupus Erythematosus: Coexistence of 2 Entities?","volume":"31","author":"Pincus L. B.","year":"2009","journal-title":"American Journal of Dermatopathology"},{"key":"e_1_2_11_11_1","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.00133","article-title":"Primary Cutaneous Gamma\u2010Delta T\u2010Cell Lymphoma With Long\u2010Term Indolent Clinical Course Initially Mimicking Lupus Erythematosus Profundus","volume":"10","author":"D\u00fccker L.","year":"2020","journal-title":"Frontiers in Oncology"}],"container-title":["Australasian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.70204","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajd.70204","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.70204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T04:53:09Z","timestamp":1788238389000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajd.70204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,31]]},"references-count":10,"alternative-id":["10.1111\/ajd.70204"],"URL":"https:\/\/doi.org\/10.1111\/ajd.70204","archive":["Portico"],"relation":{},"ISSN":["0004-8380","1440-0960"],"issn-type":[{"value":"0004-8380","type":"print"},{"value":"1440-0960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,31]]},"assertion":[{"value":"2026-05-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"ajd.70204"}}