{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:02:00Z","timestamp":1790143320220,"version":"4.0.1"},"reference-count":12,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Netherton Syndrome (NS) is a rare genodermatosis characterised by a triad of ichthyosiform erythroderma, an atopic diathesis, and trichorrhexis invaginata, for which no effective management is currently approved in Australia. Dupilumab has demonstrated considerable effectiveness in the treatment of atopic conditions in the paediatric population. We conducted a literature review to identify trends in disease aspects and their responsiveness to dupilumab treatment, with only four reports having follow\u2010up beyond 12\u2009months. To address this gap and provide insights into the long\u2010term trajectory of dupilumab treatment in this population, we report two cases of NS treated with dupilumab over 20 and 25\u2009months. This paper demonstrates that dupilumab may be a relatively safe and potentially effective option for targeting Th2\u2010mediated inflammation though its overall sustained effectiveness may be variable.<\/jats:p>","DOI":"10.1111\/ajd.70215","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:15:33Z","timestamp":1790140533000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dupilumab in Paediatric Netherton Syndrome: Two Case Reports and a Review of the Literature"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7757-6988","authenticated-orcid":false,"given":"Jacqueline","family":"Tu","sequence":"first","affiliation":[{"name":"Sydney Medical School, Faculty of Medicine and Health The University of Sydney  Sydney NSW Australia"},{"name":"Department of Dermatology The Children's Hospital at Westmead  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5938-0292","authenticated-orcid":false,"given":"Paul Sun Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Sydney Medical School, Faculty of Medicine and Health The University of Sydney  Sydney NSW Australia"},{"name":"Department of Dermatology The Children's Hospital at Westmead  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelvin","family":"Truong","sequence":"additional","affiliation":[{"name":"Sydney Medical School, Faculty of Medicine and Health The University of Sydney  Sydney NSW Australia"},{"name":"Department of Dermatology The Children's Hospital at Westmead  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Fong","sequence":"additional","affiliation":[{"name":"Sydney Medical School, Faculty of Medicine and Health The University of Sydney  Sydney NSW 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