{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:32:16Z","timestamp":1790620336804,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,10,9]],"date-time":"2012-10-09T00:00:00Z","timestamp":1349740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>Human labour is an inflammatory process with a heavy infiltration of immune cells into the myometrium and cervix induced by local chemokine production. Myometrial cells also express chemokine receptors, but there is little information about their behaviour or function during pregnancy and labour.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of Study<\/jats:title><jats:p>We studied the behaviour of the receptors (<jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>2, <jats:styled-content style=\"fixed-case\">CXCR<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">CXCR<\/jats:styled-content>2) for the <jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>2 and <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>8 in human myometrium, because both have been shown to be important in labour.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that there was a significant decline in the m<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> expression of all three receptors in the upper segment and a similar trend in the lower segment with the onset of term labour (TL). Chemokine receptor m<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> expression was increased by stretch, reduced by oxytocin and <jats:styled-content style=\"fixed-case\">PGF<\/jats:styled-content><jats:sub>2\u03b1<\/jats:sub> acting via phospholipase <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">PLC<\/jats:styled-content>). <jats:styled-content style=\"fixed-case\">CXCR<\/jats:styled-content>2 declined with exposure to <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>8, consistent with the negative relationship observed in labouring myometrial tissue. The m<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> changes were confirmed by western analysis and flow cytometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These data show that myometrial chemokine receptor expression is reduced with the onset of term labour probably in response to the increased activity of chemokines, oxytocin and PGF<jats:sub>2\u03b1<\/jats:sub>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12025","type":"journal-article","created":{"date-parts":[[2012,10,9]],"date-time":"2012-10-09T06:41:16Z","timestamp":1349764876000},"page":"21-32","source":"Crossref","is-referenced-by-count":9,"title":["Human Labour is Associated with a Decline in Myometrial Chemokine Receptor Expression: The Role of Prostaglandins, Oxytocin and Cytokines"],"prefix":"10.1111","volume":"69","author":[{"given":"Renyi","family":"Hua","sequence":"first","affiliation":[{"name":"Imperial College Parturition Research Group Academic Department of Obstetrics &amp; Gynaecology Imperial College School of Medicine Chelsea and Westminster Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Pease","sequence":"additional","affiliation":[{"name":"Leukocyte Biology Section National Heart &amp; Lung Institute Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Cheng","sequence":"additional","affiliation":[{"name":"The International Peace Maternity and Child Health Hospital Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suren R.","family":"Sooranna","sequence":"additional","affiliation":[{"name":"Imperial College Parturition Research Group Academic Department of Obstetrics &amp; Gynaecology Imperial College School of Medicine Chelsea and Westminster Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"Viney","sequence":"additional","affiliation":[{"name":"Leukocyte Biology Section National Heart &amp; Lung Institute Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott M.","family":"Nelson","sequence":"additional","affiliation":[{"name":"School of Medicine University of Glasgow Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Les","family":"Myatt","sequence":"additional","affiliation":[{"name":"Center for Pregnancy and Newborn Research University of Texas Health Science Center San Antonio San Antonio TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip R.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Imperial College Parturition Research Group Academic Department of Obstetrics &amp; Gynaecology Imperial College School of Medicine Chelsea and Westminster Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Imperial College Parturition Research Group Academic Department of Obstetrics &amp; 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