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Sexual trauma can also occur as a result of female genital mutilation, which makes sex extremely painful and can cause increased abrasions, lacerations, and inflammation, which enhances the risk of <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> acquisition. This review presents an overview of the immune system in the human female reproductive tract (<jats:styled-content style=\"fixed-case\">FRT<\/jats:styled-content>) from adolescence, through puberty to pregnancy and menopause. What is clear is that the foundation of information on immune protection in the <jats:styled-content style=\"fixed-case\">FRT<\/jats:styled-content> throughout the life cycle of women is extremely limited and at some stages such as adolescence and menopause are grossly lacking. 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