{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T03:12:52Z","timestamp":1783566772914,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,10,11]],"date-time":"2012-10-11T00:00:00Z","timestamp":1349913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>Local adaptive cervical regulatory T cells (Tregs) are the most likely direct suppressors of the immune eradication of cervical intraepithelial lesion (CIN). PD\u20101 expression on T cells induces Tregs. No studies have quantitatively analyzed the Tregs and PD\u20101+ cells residing in CIN lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>Cervical lymphocytes were collected using cytobrushes from CIN patients and analyzed by FACS analysis. Comparisons were made between populations of cervical Tregs and PD\u20101+ CD4+ T cells in CIN regressors and non\u2010regressors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A median of 11% of cervical CD4+ T cells were Tregs, while a median of 30% were PD\u20101+ cells. The proportions of cervical CD4+ T cells that were Tregs and\/or PD\u20101+ cells were significantly lower in CIN regressors when compared with non\u2010regressors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The prevalence of cervical tolerogenic T cells correlates inversely with spontaneous regression of CIN. 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