{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:45:04Z","timestamp":1761101104278},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,10,16]],"date-time":"2012-10-16T00:00:00Z","timestamp":1350345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2013,2]]},"abstract":"Problem<\/jats:title>The aim of our study was to estimate the expressions of both B7\u2010H1 and B7\u2010H4 as well as CD<\/jats:styled-content>200 and CD<\/jats:styled-content>200R co\u2010stimulatory molecules on immature myeloid and lymphoid dendritic cells, B CD<\/jats:styled-content>19+<\/jats:sup> lymphocytes and monocytes in umbilical cord blood of healthy neonates and in peripheral blood of healthy adults.<\/jats:p><\/jats:sec>Method of study<\/jats:title>Thirty\u2010nine healthy full\u2010term neonates from physiological single pregnancies and 27 healthy adults were included in the study. The expressions of B7\u2010H1, B7\u2010H4, CD<\/jats:styled-content>200, CD<\/jats:styled-content>200R antigens were estimated using flow cytometry. Statistical analysis was performed using a non\u2010parametric Mann\u2013Whitney U<\/jats:italic>\u2010test and parametric Wilcoxon's test.<\/jats:p><\/jats:sec>Results<\/jats:title>The expressions of B7\u2010H1 and B7\u2010H4 molecules on immature BDCA<\/jats:styled-content>\u20101+<\/jats:sup> myeloid dendritic cells were significantly lower in umbilical cord blood of healthy neonates when compared with those cells in peripheral blood of healthy adults (P<\/jats:italic>\u00a0<\u00a00.0001). Furthermore, the suppression of B7\u2010H4 molecule on BDCA\u20102+<\/jats:sup> lymphoid dendritic cells was observed in cord blood of healthy neonates when compared with peripheral blood of healthy adults (P<\/jats:italic>\u00a0<\u00a00.02). The expressions of CD<\/jats:styled-content>200 antigen on BDCA<\/jats:styled-content>\u20101+<\/jats:sup> cells, CD<\/jats:styled-content>200R antigen on BDCA<\/jats:styled-content>\u20102+<\/jats:sup> cells and CD<\/jats:styled-content>200R antigen on B CD<\/jats:styled-content>19+<\/jats:sup> cells were significantly lower in cord blood of healthy neonates. On the other hand, the expressions of CD<\/jats:styled-content>200 and CD<\/jats:styled-content>200R as well as B7\u2010H4 co\u2010stimulatory molecules on CD<\/jats:styled-content>14+<\/jats:sup> cells were significantly higher in cord blood when compared with peripheral blood.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The increased percentages of CD<\/jats:styled-content>14+<\/jats:sup> monocytes with the expressions of CD<\/jats:styled-content>200 and CD<\/jats:styled-content>200R as well as B7\u2010H4 co\u2010stimulatory molecules can suggest the increased immunomodulatory properties of neonatal monocytes in cord blood.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12031","type":"journal-article","created":{"date-parts":[[2012,10,16]],"date-time":"2012-10-16T09:38:37Z","timestamp":1350380317000},"page":"180-187","source":"Crossref","is-referenced-by-count":3,"title":["The Expressions of Co\u2010Stimulatory Molecules are Altered on Putative Antigen\u2010Presenting Cells in Cord Blood"],"prefix":"10.1111","volume":"69","author":[{"given":"Dorota","family":"Darmochwal\u2010Kolarz","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Perinatology Medical University of Lublin Lublin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Serafin","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Medical University of Lublin Lublin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek","family":"Tabarkiewicz","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Medical University of Lublin Lublin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogdan","family":"Kolarz","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Medical University of Lublin Lublin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek","family":"Rolinski","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Medical University of Lublin Lublin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Oleszczuk","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Perinatology Medical University of Lublin Lublin 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