{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:15:47Z","timestamp":1761988547050},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,12,17]],"date-time":"2012-12-17T00:00:00Z","timestamp":1355702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>Toll\u2010like receptors (TLRs) are innate immune receptors that mediate the pattern recognition of, and response toward, pathogens and host\u2010derived danger signals. We reported that cyclooxygenase\u20102 (COX\u20102) and microsomal prostaglandin <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> synthase (<jats:styled-content style=\"fixed-case\">mPGES<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> were expressed in cases of endometriosis. The relationship between <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102, <jats:styled-content style=\"fixed-case\">mPGES<\/jats:styled-content>\u20101, and <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>4 in endometriotic lesions has yet to be determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>Endometriosis samples were obtained from 37 patients with endometrial cysts. Endometrial tissues were obtained from patients undergoing surgical procedures for benign gynecological conditions. <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102, <jats:styled-content style=\"fixed-case\">mPGES<\/jats:styled-content>\u20101, and <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>4 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expressions were examined by real\u2010time quantitative reverse transcription <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">qRT<\/jats:styled-content>\u2010PCR) and <jats:styled-content style=\"fixed-case\">mPGES<\/jats:styled-content>\u20101, and <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>4 protein localization was examined by immunohistochemistry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>TLR4 proteins were mostly located to the glandular epithelium. The immunoreactivities of <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>4 and <jats:styled-content style=\"fixed-case\">mPGES<\/jats:styled-content>\u20101 from endometriosis lesions were significantly higher than those in eutopic endometrium in the proliferative phase. The expression levels of <jats:styled-content style=\"fixed-case\">mPGES<\/jats:styled-content>\u20101 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> in peritoneal endometriosis were higher than those in eutopic endometrium in the proliferative phase. The expression of <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>4 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> correlates with that of <jats:styled-content style=\"fixed-case\">mPGES<\/jats:styled-content>\u20101 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> and not with that of <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102 in endometriotic lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Relationship between <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>4 and <jats:styled-content style=\"fixed-case\">mPGES<\/jats:styled-content>\u20101 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> in endometriotic lesions indicate that innate immunity may play an important role in the pathogenesis of endometriosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12056","type":"journal-article","created":{"date-parts":[[2012,12,18]],"date-time":"2012-12-18T17:43:06Z","timestamp":1355852586000},"page":"231-239","source":"Crossref","is-referenced-by-count":18,"title":["Relationship Between Toll\u2010like Receptor\u20104 and <scp>mPGES<\/scp>\u20101 Gene Expression in Local Lesions of Endometriosis Patients"],"prefix":"10.1111","volume":"69","author":[{"given":"Chuyu","family":"Hayashi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Nihon University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumihisa","family":"Chishima","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nihon University School of Medicine Tokyo 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