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However, the identification of new and more reliable<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>reg markers during the last years resulted in some controversies about the kinetics of various<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>reg subsets at different pregnancy stages. No doubt exists regarding the importance of<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>reg for a normal pregnancy as pregnancy complications like spontaneous abortion and preeclampsia could be associated with a reduced<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>reg number and activity. In future, more attention should be paid to bring established data from the bench to the bedside to force the development of adequate therapies for treatment of pregnancy complications. 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