{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:59:46Z","timestamp":1789750786614,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,1,28]],"date-time":"2013-01-28T00:00:00Z","timestamp":1359331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:p>\n                    B lymphocytes are pleiotropic cells belonging to the adaptive arm of the immune system. Although\n                    <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\n                    cells were classically regarded for their capacity to produce antibodies, in the recent years, several other functions were attributed to these cells. B cells can uptake, process and present antigens as well as produce several cytokines that further influence immunity.Mammalian pregnancies represent a fascinating phenomenon in which the maternal immune system must be able to \u2018tolerate\u2019 the semi\u2010allogenic fetus while simultaneously protecting the mother and the fetus against external pathogens. This requires a finely regulated balance between immune activation and tolerance. In this regard,\n                    <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\n                    cells and the antibodies they produced were shown to actively participate in both, pregnancy well\u2010being as well as pregnancy\u2010associated pathologies.We discuss here the currently available information concerning the role of\n                    <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\n                    cells in the context of pregnancy.\n                  <\/jats:p>","DOI":"10.1111\/aji.12079","type":"journal-article","created":{"date-parts":[[2013,1,28]],"date-time":"2013-01-28T05:26:33Z","timestamp":1359350793000},"page":"408-412","source":"Crossref","is-referenced-by-count":81,"title":["The Role of\n                    <scp>B<\/scp>\n                    Cells in Pregnancy: the Good and the Bad"],"prefix":"10.1111","volume":"69","author":[{"given":"Dami\u00e1n","family":"Muzzio","sequence":"first","affiliation":[{"name":"Experimental Obstetrics and Gynaecology Medical Faculty Otto\u2010von\u2010Guericke\u2010University Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Claudia","family":"Zenclussen","sequence":"additional","affiliation":[{"name":"Experimental Obstetrics and Gynaecology Medical Faculty Otto\u2010von\u2010Guericke\u2010University Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Jensen","sequence":"additional","affiliation":[{"name":"Experimental Obstetrics and Gynaecology Medical Faculty Otto\u2010von\u2010Guericke\u2010University Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-02-078071"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1313.003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.2001.00950.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2011.06137.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(07)95001-4"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri799"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101499"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2006.07.005"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20110978"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.20.100301.064833"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2005.10.007"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1972.tb00057.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1981.tb00714.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1976.tb01056.x"},{"key":"e_1_2_7_16_1","first-page":"973","article-title":"Antigenicity of trophoblast and possible antigen\u2010masking effects during pregnancy","volume":"28","author":"Taylor PV","year":"1975","journal-title":"Immunology"},{"key":"e_1_2_7_17_1","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.4049\/jimmunol.132.5.2305","article-title":"Immunoactive products of placenta. III. Suppression of natural killing activity","volume":"132","author":"Kolb JP","year":"1984","journal-title":"J Immunol"},{"key":"e_1_2_7_18_1","first-page":"1","article-title":"Immunology of abortion","volume":"60","author":"Mowbray JF","year":"1985","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)91078-4"},{"key":"e_1_2_7_20_1","first-page":"77","article-title":"Immunogenetic studies of recurrent spontaneous abortions in humans","volume":"2","author":"Johnson PM","year":"1985","journal-title":"Exp Clin Immunogenet"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0019-2791(76)90217-2"},{"key":"e_1_2_7_22_1","first-page":"311","article-title":"Structure of asymmetric non\u2010precipitating antibody: presence of a carbohydrate residue in only one Fab region of the molecule","volume":"57","author":"Labeta MO","year":"1986","journal-title":"Immunology"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0378(91)90029-P"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.8755-8920.2001.450504.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0897.2002.01125.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1006\/cimm.1996.0016"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1989.tb01016.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(11)90692-9"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00304500"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199102000-00029"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2011.10.006"},{"key":"e_1_2_7_32_1","first-page":"501","article-title":"Some patients with primary antiphospholipid syndrome have increased circulating CD5+\u00a0 B cells that correlate with levels of IgM antiphospholipid antibodies","volume":"9","author":"Velasquillo MC","year":"1991","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767050802034545"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.12.049"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1856"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.188276"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0378(94)00907-O"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.167569"}],"container-title":["American Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faji.12079","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aji.12079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T22:31:04Z","timestamp":1694385064000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aji.12079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,28]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1111\/aji.12079"],"URL":"https:\/\/doi.org\/10.1111\/aji.12079","archive":["Portico"],"relation":{},"ISSN":["1046-7408","1600-0897"],"issn-type":[{"value":"1046-7408","type":"print"},{"value":"1600-0897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,28]]}}}