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This entails the coordination of multiple cellular processes all devoted to accommodate and nourish the fetus while protecting the mother from endogenous and exogenous threatens. From the earliest stages of pregnancy, several strategies to efficiently communicate immune and trophoblast cells within the interface or at a distance were identified and chemokines might act at on different targets through direct or indirect mechanisms. Here, we briefly review some mechanisms of T regulatory cell recruitment to the early maternal\u2013placental interfaces to accomplish immunotolerance and homeostatic control and we discuss evidence on two locally released polypeptides, <jats:styled-content style=\"fixed-case\">RANTES<\/jats:styled-content> (regulated on activation, normal, <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010cell expressed, and secreted) and vasoactive intestinal peptide (VIP), as novel contributors to the multiplicity of immune tolerant responses and uterine quiescence requirements.<\/jats:p>","DOI":"10.1111\/aji.12087","type":"journal-article","created":{"date-parts":[[2013,2,14]],"date-time":"2013-02-14T09:02:41Z","timestamp":1360832561000},"page":"359-368","source":"Crossref","is-referenced-by-count":14,"title":["Tolerance Induction at the Early Maternal\u2013Placental Interface Through Selective Cell Recruitment and Targeting by Immune Polypeptides"],"prefix":"10.1111","volume":"69","author":[{"given":"Claudia","family":"P\u00e9rez Leir\u00f3s","sequence":"first","affiliation":[{"name":"Immunopharmacology Laboratory School of Sciences University of Buenos Aires IQUIBICEN\u2010CONICET Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosanna","family":"Ramhorst","sequence":"additional","affiliation":[{"name":"Immunopharmacology Laboratory School of Sciences University of Buenos Aires IQUIBICEN\u2010CONICET Buenos Aires 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