{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T06:52:06Z","timestamp":1759042326908},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,6,11]],"date-time":"2013-06-11T00:00:00Z","timestamp":1370908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>Differences in the expression of gp96 and its receptors were analysed in normal and pathological human pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Immunohistology and immunofluorescence of sections from decidual part of term placenta, first trimester normal decidua, missed abortion and blighted ovum decidua were performed together with reverse transcriptase\u2013quantitative polymerase chain reaction and flow cytometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In missed abortion, gp96 was intensively stained, when compared to normal early pregnancy. The intensity of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>91 and <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>4 was higher in the first trimester pregnancy and blighted ovum, when compared to missed abortion. Decidual part of the term placenta is invaded with gp96<jats:sup>+<\/jats:sup>, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>91<jats:sup>+<\/jats:sup> and <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>4+ trophoblast. Progesterone\u2010induced blocking factor (<jats:styled-content style=\"fixed-case\">PIBF<\/jats:styled-content>) decreased the frequency of <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>4<jats:sup>+<\/jats:sup> T lymphocytes, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>91<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>, natural killer (<jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content>) and mature dendritic cells after an 18\u2010h culture. Decidual mononuclear cells (<jats:styled-content style=\"fixed-case\">DMC<\/jats:styled-content>s) treated with <jats:styled-content style=\"fixed-case\">PIBF<\/jats:styled-content> down\u2010regulated <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>91, <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>4 and gp96 gene expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The presence of gp96, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>91 and <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>4 at the maternal\u2013foetal interface provides a molecular basis for their interaction, particularly in the absence of <jats:styled-content style=\"fixed-case\">PIBF<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12096","type":"journal-article","created":{"date-parts":[[2013,6,11]],"date-time":"2013-06-11T12:09:02Z","timestamp":1370952542000},"page":"10-23","source":"Crossref","is-referenced-by-count":8,"title":["The Significance of Heat\u2010Shock Protein <scp>GP<\/scp>96 and its Receptors' <scp>CD<\/scp>91 and Toll\u2010Like Receptor 4 Expression at the Maternal Foetal Interface"],"prefix":"10.1111","volume":"70","author":[{"given":"Tamara","family":"Gulic","sequence":"first","affiliation":[{"name":"Department of Physiology and Immunology Medical Faculty University of Rijeka Rijeka Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordana","family":"Laskarin","sequence":"additional","affiliation":[{"name":"Department of Physiology and Immunology Medical Faculty University of Rijeka Rijeka Croatia"},{"name":"Division of Cardiology Hospital for Medical Rehabilitation of the Hearth 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