{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T15:27:02Z","timestamp":1780414022415,"version":"3.54.1"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T00:00:00Z","timestamp":1361923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201022 has important functions at mucosal surfaces, including the induction of antimicrobial peptides and maintenance of epithelium. However, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201022 has not been investigated in the genital tract during <jats:styled-content style=\"fixed-case\">TV<\/jats:styled-content> infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods of Study<\/jats:title><jats:p>Women who visited an <jats:styled-content style=\"fixed-case\">STD<\/jats:styled-content> clinic and women from a cohort with frequent Trichomoniasis were studied. <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201022, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017, and antimicrobial peptides were measured in cervicovaginal lavage by <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In women visiting the <jats:styled-content style=\"fixed-case\">STD<\/jats:styled-content> clinic, those without <jats:styled-content style=\"fixed-case\">STD<\/jats:styled-content>s (<jats:italic>n<\/jats:italic>\u00a0=\u00a010) had a median <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201022 of 0\u00a0pg\/mL, while women with infections (<jats:italic>n<\/jats:italic>\u00a0=\u00a030) had 27\u00a0pg\/mL (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04). In the cohort, women with Trichomoniasis (<jats:italic>n<\/jats:italic>\u00a0=\u00a019) had significantly higher <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201022 than women with no infections (<jats:italic>n<\/jats:italic>\u00a0=\u00a021, 74 versus 0\u00a0pg\/mL, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0001). <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 was also significantly increased in Trichomoniasis, and there was a correlation between <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201022 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201022 is increased in <jats:styled-content style=\"fixed-case\">STD<\/jats:styled-content>s generally and in Trichomoniasis specifically suggesting an antimicrobial response of the mucosa and an epithelial repair process induced by the <jats:styled-content style=\"fixed-case\">STD<\/jats:styled-content>s.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12100","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T15:11:03Z","timestamp":1361977863000},"page":"38-44","source":"Crossref","is-referenced-by-count":17,"title":["<scp>IL<\/scp>\u201022 Levels are Associated with <i>Trichomonas vaginalis<\/i> Infection in the Lower Genital Tract"],"prefix":"10.1111","volume":"70","author":[{"given":"Hadijat Moradeke","family":"Makinde","sequence":"first","affiliation":[{"name":"Department of Immunology\/Microbiology Rush University Medical Center Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Zariffard","sequence":"additional","affiliation":[{"name":"Department of Immunology\/Microbiology Rush University Medical Center Chicago IL 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory T","family":"Spear","sequence":"additional","affiliation":[{"name":"Department of Immunology\/Microbiology Rush University Medical Center Chicago IL 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