{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T17:50:16Z","timestamp":1789321816040,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,4,25]],"date-time":"2013-04-25T00:00:00Z","timestamp":1366848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>Uterine leiomyomata are the most common reproductive tumor in women, and their cause is not known.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods of Study<\/jats:title><jats:p>Plasma samples from 155 women (74 with and 81 without ultrasound\u2010confirmed leiomyoma) from a new study of leiomyoma risk factors in the Detroit, Michigan area, were examined for any cross\u2010sectional associations between commonly examined cytokines and leiomyoma presence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Associations varied by season of sample collection defined <jats:italic>a priori<\/jats:italic> as winter (December\u2013February) and non\u2010winter seasons. In the winter months, interleukin (IL)13 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>17 were positively and <jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>10 was inversely associated with having a leiomyoma. In the non\u2010winter samples, <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>, G\u2010<jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>10 were positively associated and Monocyte chemotactic protein\u20101, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>13, and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>17 were inversely associated with having a leiomyoma. Associations were not changed by adjustment for age or <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These data suggest that new insight into leiomyoma formation may be acquired through investigation of the immune system.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12127","type":"journal-article","created":{"date-parts":[[2013,4,25]],"date-time":"2013-04-25T10:46:53Z","timestamp":1366886813000},"page":"327-335","source":"Crossref","is-referenced-by-count":19,"title":["Cytokine Patterns Differ Seasonally between Women with and without Uterine Leiomyomata"],"prefix":"10.1111","volume":"70","author":[{"given":"Ganesa","family":"Wegienka","sequence":"first","affiliation":[{"name":"Department of Public Health Sciences Henry Ford Hospital Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Day Baird","sequence":"additional","affiliation":[{"name":"Epidemiology Branch Department of Health and Human Services National Institute of Environmental Health Sciences The National Institutes of Health Research Triangle Park NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Cooper","sequence":"additional","affiliation":[{"name":"Division of Ultrasound Department of Diagnostic Radiology Henry Ford Hospital Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberley J.","family":"Woodcroft","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Henry Ford Hospital Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Havstad","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Henry Ford Hospital Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.07.008"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.99"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(02)03121-6"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000234651.41000.58"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200202000-00012"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2012.04.046"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.17.1459"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0493"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2809"},{"key":"e_1_2_7_11_1","first-page":"89","volume-title":"Microbes and Malignancy. 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