{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:01:59Z","timestamp":1763017319846},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,9,13]],"date-time":"2013-09-13T00:00:00Z","timestamp":1379030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>The purpose of this study is to evaluate the involvement of death receptor (<jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>) 6 in the pathogenesis of endometriosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods of study<\/jats:title><jats:p>Endometriotic cyst stromal cells (<jats:styled-content style=\"fixed-case\">ECSC<\/jats:styled-content>s) and normal endometrial stromal cells (<jats:styled-content style=\"fixed-case\">NESC<\/jats:styled-content>s) were isolated from ovarian endometriotic tissues and the eutopic endometrial tissues, respectively. The effect of valproic acid (<jats:styled-content style=\"fixed-case\">VPA<\/jats:styled-content>) on the <jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>6 expression in <jats:styled-content style=\"fixed-case\">ECSC<\/jats:styled-content>s was examined. The roles of <jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>6 in <jats:styled-content style=\"fixed-case\">NESC<\/jats:styled-content> proliferation and apoptosis were investigated with <jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>6 si<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> transfection. The distribution of <jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>6 protein in ovarian endometriotic tissues and normal proliferative\u2010phase endometrium was examined by immunohistochemistry. The expression of <jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>6 m<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> and protein in <jats:styled-content style=\"fixed-case\">ECSC<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">NESC<\/jats:styled-content>s was also examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Death receptor 6 expression was attenuated in <jats:styled-content style=\"fixed-case\">ECSC<\/jats:styled-content>s and in endometriotic tissues, and its expression was upregulated by <jats:styled-content style=\"fixed-case\">VPA<\/jats:styled-content> stimulation. <jats:styled-content style=\"fixed-case\">VPA<\/jats:styled-content> treatment resulted in an accumulation of acetylated histone <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>4 in the promoter region of the <jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>6 gene. <jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>6 knockdown directed the stimulation of cell proliferation and the resistance to apoptosis in <jats:styled-content style=\"fixed-case\">NESC<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present findings suggested that DR6 is involved in the pathogenesis of endometriosis by creating the proliferative and anti\u2010apoptotic characteristics of endometriosis. The results also suggest that histone deacetylase inhibitors are promising agents for the treatment of endometriosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12155","type":"journal-article","created":{"date-parts":[[2013,9,13]],"date-time":"2013-09-13T05:49:58Z","timestamp":1379051398000},"page":"485-496","source":"Crossref","is-referenced-by-count":14,"title":["<scp>D<\/scp>eath <scp>R<\/scp>eceptor 6 is <scp>E<\/scp>pigenetically <scp>S<\/scp>ilenced by <scp>H<\/scp>istone <scp>D<\/scp>eacetylation in <scp>E<\/scp>ndometriosis and <scp>P<\/scp>romotes the <scp>P<\/scp>athogenesis of <scp>E<\/scp>ndometriosis"],"prefix":"10.1111","volume":"70","author":[{"given":"Kentaro","family":"Kai","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Oita University Yufu\u2010shi Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaei","family":"Nasu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology 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