{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:48:28Z","timestamp":1791251308301,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,10,10]],"date-time":"2013-10-10T00:00:00Z","timestamp":1381363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec>\n                    <jats:title>Problem<\/jats:title>\n                    <jats:p>\n                      The function of\n                      <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                      \u201010 producing regulatory B cells (Breg) during gestation is unknown. Here, we aimed to understand their participation in early pregnancy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                      19\n                      <jats:sup>+<\/jats:sup>\n                      <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                      24\n                      <jats:sup>hi<\/jats:sup>\n                      <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                      27\n                      <jats:sup>+<\/jats:sup>\n                      B cell frequency, measured by flow cytometry, increased with pregnancy onset but not in the case of spontaneous abortions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      B cells from non\u2010pregnant women cultured with serum from normal pregnant women produced higher IL\u201010 levels than those cultured with serum from spontaneous abortion patients or autologous serum. CD19\n                      <jats:sup>+<\/jats:sup>\n                      \u2010activated B cells from pregnant women strongly suppressed TNF\u2010a production by CD4\n                      <jats:sup>+<\/jats:sup>\n                      T cells when cocultured. We identified\n                      <jats:styled-content style=\"fixed-case\">hCG<\/jats:styled-content>\n                      as an important factor regulating the number and function of Breg during pregnancy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Breg emerge as important players in pregnancy; they suppress undesired immune responses from maternal T cells and are therefore important for tolerance acquisition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aji.12157","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T22:09:05Z","timestamp":1381529345000},"page":"448-453","source":"Crossref","is-referenced-by-count":154,"title":["<scp>Cutting Edge: IL<\/scp>\n                    \u201010\u2010Producing Regulatory B Cells in Early Human Pregnancy"],"prefix":"10.1111","volume":"70","author":[{"given":"Luise","family":"Rolle","sequence":"first","affiliation":[{"name":"Experimental Obstetrics and Gynaecology Medical Faculty Otto\u2010von\u2010Guericke\u2010University Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Memarzadeh Tehran","sequence":"additional","affiliation":[{"name":"Experimental Obstetrics and Gynaecology Medical Faculty Otto\u2010von\u2010Guericke\u2010University Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anselm","family":"Morell\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Experimental Obstetrics and Gynaecology Medical Faculty Otto\u2010von\u2010Guericke\u2010University Magdeburg Germany"},{"name":"University Pompeu Fabra Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanitsa","family":"Raeva","sequence":"additional","affiliation":[{"name":"University Women's Clinic Otto\u2010von\u2010Guericke\u2010University Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Schumacher","sequence":"additional","affiliation":[{"name":"Experimental Obstetrics and Gynaecology Medical Faculty Otto\u2010von\u2010Guericke\u2010University Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Hartig","sequence":"additional","affiliation":[{"name":"Institute for Molecular and Clinical Immunology Medical Faculty Otto\u2010von\u2010Guericke\u2010University Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serban\u2010Dan","family":"Costa","sequence":"additional","affiliation":[{"name":"University Women's Clinic Otto\u2010von\u2010Guericke\u2010University Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Jensen","sequence":"additional","affiliation":[{"name":"Experimental Obstetrics and Gynaecology Medical Faculty Otto\u2010von\u2010Guericke\u2010University Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Claudia","family":"Zenclussen","sequence":"additional","affiliation":[{"name":"Experimental Obstetrics and Gynaecology Medical Faculty Otto\u2010von\u2010Guericke\u2010University Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,10]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2011.06137.x"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.2741\/2737"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-020711-074934"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-07-294249"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.8755-8920.2001.450504.x"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(99)00505-1"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.188276"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni833"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.02.042"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803052"}],"container-title":["American 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