{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T20:59:02Z","timestamp":1771102742552,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,9,13]],"date-time":"2013-09-13T00:00:00Z","timestamp":1379030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>To investigate whether thymic stromal lymphopoietin (<jats:styled-content style=\"fixed-case\">TSLP<\/jats:styled-content>) regulates the apoptosis of decidual \u03b3\u03b4 <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells and to elucidate the mechanism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>Primary human decidual \u03b3\u03b4 <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells were treated with <jats:styled-content style=\"fixed-case\">TSLP<\/jats:styled-content> only or <jats:styled-content style=\"fixed-case\">TSLP<\/jats:styled-content> combined with different signaling inhibitors (<jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>3, <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>5, <jats:styled-content style=\"fixed-case\">AKT<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">ERK<\/jats:styled-content>). The levels of signal transduction and activation of transcription 3 (<jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>3) tyrosine phosphorylation and caspase3 expression were determined using Western blot analysis, and the apoptosis of decidual \u03b3\u03b4 <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells was analyzed by flow cytometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The proportions of \u03b3\u03b4 <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells in the peripheral circulation and in decidual <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>3<jats:sup>+<\/jats:sup> cell population in women with normal pregnancy were higher than the proportions of \u03b3\u03b4 T cells in either non\u2010pregnant control or miscarriage. Decidual \u03b3\u03b4 <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells co\u2010expressed the <jats:styled-content style=\"fixed-case\">TSLP<\/jats:styled-content> receptors (<jats:styled-content style=\"fixed-case\">TSLPR<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20107R\u03b1, and the expression of <jats:styled-content style=\"fixed-case\">TSLPR<\/jats:styled-content> in decidual \u03b3\u03b4 <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells was higher than that in decidual <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> T cells. Treatment with <jats:styled-content style=\"fixed-case\">TSLP<\/jats:styled-content> significantly suppressed the apoptosis of decidual \u03b3\u03b4 <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells and enhanced <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>3 phosphorylation. Moreover, <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>3, and not other inhibitors, completely abrogated the anti\u2010apoptotic effect and expression of caspase3 in decidual \u03b3\u03b4 <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells induced by recombinant human <jats:styled-content style=\"fixed-case\">TSLP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results suggest that <jats:styled-content style=\"fixed-case\">TSLP<\/jats:styled-content> may down\u2010regulate caspase3 expression through activation of the <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>3 pathway, thereby suppressing the apoptosis of decidual \u03b3\u03b4 <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12158","type":"journal-article","created":{"date-parts":[[2013,9,13]],"date-time":"2013-09-13T06:10:52Z","timestamp":1379052652000},"page":"464-471","source":"Crossref","is-referenced-by-count":14,"title":["Thymic Stromal Lymphopoietin Suppresses the Apoptosis of Decidual Gamma\u2010delta <scp>T<\/scp> Cells via Regulation of the Signal Transduction and Activation of Transcription 3\/Caspase\u20103 Signaling Pathway"],"prefix":"10.1111","volume":"70","author":[{"given":"Jie","family":"Duan","sequence":"first","affiliation":[{"name":"Laboratory for Reproductive Immunology Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Hospital and Institute of Obstetrics and Gynecology Fudan University Shanghai Medical College Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Ping","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics 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