{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T01:50:19Z","timestamp":1783993819370,"version":"3.55.0"},"reference-count":74,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,11,14]],"date-time":"2013-11-14T00:00:00Z","timestamp":1384387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p><jats:italic>Chlamydia trachomatis<\/jats:italic> infections are a significant cause of reproductive tract pathology. Protective and pathological immune mediators must be differentiated to design a safe and effective vaccine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Wild\u2010type mice and mice deficient in <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201022 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023 were infected intravaginally with <jats:italic><jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hlamydia muridarum,<\/jats:italic> and their course of infection and oviduct pathology were compared. Local genital tract and draining lymph node immune responses were also examined in <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023\u2010deficient mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201022\u2010 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023\u2010deficient mice exhibited normal susceptibility to infection and oviduct pathology. <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023 was required for the development of a <jats:italic><jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hlamydia<\/jats:italic>\u2010specific Th17 response in the lymph nodes and for production of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201022 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 in the genital tract. However, influx of <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h1 and innate immune cells was not compromised in the absence of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201022 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023 play either redundant or minimal roles in the pathogenesis of <jats:italic><jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hlamydia<\/jats:italic> infection in the mouse model. Induction of <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h17\u2010associated cytokines by a <jats:italic><jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hlamydia<\/jats:italic> vaccine should be avoided as these responses are not central to resolution of infection and have pathologic potential.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12171","type":"journal-article","created":{"date-parts":[[2013,11,15]],"date-time":"2013-11-15T05:13:49Z","timestamp":1384492429000},"page":"472-484","source":"Crossref","is-referenced-by-count":36,"title":["<scp>IL<\/scp>\u201023 Induces <scp>IL<\/scp>\u201022 and <scp>IL<\/scp>\u201017 Production in Response to <i><scp>C<\/scp>hlamydia muridarum<\/i> Genital Tract Infection, but the Absence of these Cytokines does not Influence Disease Pathogenesis"],"prefix":"10.1111","volume":"70","author":[{"given":"Lauren C.","family":"Frazer","sequence":"first","affiliation":[{"name":"Department of Immunology University of 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