{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T23:27:33Z","timestamp":1789946853575,"version":"4.0.1"},"reference-count":74,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,11,15]],"date-time":"2013-11-15T00:00:00Z","timestamp":1384473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>Interleukin\u20101\u03b2 (IL\u20101\u03b2) is a pro\u2010inflammatory cytokine that is involved in human parturition, especially in the context of infection\u2010induced preterm birth. Caspase\u20101 is a key component of inflammasomes, which are activated upon infection to trigger the maturation of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>To determine the effect of human labour on caspase\u20101 activation in human foetal membranes and myometrium. In addition, the mechanisms by which inflammasome activation regulates <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2 production were also be assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Higher caspase\u20101 gene and protein expression were detected in foetal membranes myometrium obtained from term labouring women when compared with samples taken from non labouring women. Lipopolysaccharide induced the transcription and secretion of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2 from foetal membranes and myometrium; both events were dependent on nuclear factor kappa B (<jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010\u03baB). However, levels of extracellular <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2 were greatly increased by subsequent treatment with the potassium\u2010proton ionophore Adenosine triphosphate (ATP) or nigericin; an effect that was dependent on active caspase\u20101. Additionally, <jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content> induced <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2 secretion via the purinergic P2X7 receptor, whereas the pannexin\u20101 channel was required for nigericin induced <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2 secretion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Taken together, these results demonstrate that caspase\u20101 activation is increased with human labour in foetal membranes and myometrium, and is required for infection\u2010induced <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2 secretion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12174","type":"journal-article","created":{"date-parts":[[2013,11,15]],"date-time":"2013-11-15T06:12:58Z","timestamp":1384495978000},"page":"189-201","source":"Crossref","is-referenced-by-count":32,"title":["Caspase\u20101 Activation is Increased with Human Labour in Foetal Membranes and Myometrium and Mediates Infection\u2010Induced Interleukin\u20101\u03b2 Secretion"],"prefix":"10.1111","volume":"71","author":[{"given":"Martha","family":"Lappas","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of Melbourne Heidelberg Vic. 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