{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T21:47:35Z","timestamp":1784238455706,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T00:00:00Z","timestamp":1393200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>Cytomegalovirus (<jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content>) infection was previously reported in pregnancy complications. However, its seroprevalence and associated Toll\u2010like receptor (<jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>) expression in early\u2010onset preeclampsia (<jats:styled-content style=\"fixed-case\">EOPE<\/jats:styled-content>) with hemolysis, elevated liver enzyme and low platelets syndrome (<jats:styled-content style=\"fixed-case\">HELLP<\/jats:styled-content>s) are unexplored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>A case\u2013control study was performed to examine maternal <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> antibodies, neutrophil Toll\u2010like receptor (<jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>)\u20102 and \u20104 expression as well as the cytokine profile in <jats:styled-content style=\"fixed-case\">EOPE<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">HELLP<\/jats:styled-content>s (<jats:styled-content style=\"fixed-case\">EOPE<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HELLP<\/jats:styled-content>s) (<jats:italic>n<\/jats:italic>\u00a0=\u00a010), late\u2010onset preeclampsia (<jats:styled-content style=\"fixed-case\">LOPE<\/jats:styled-content>) (<jats:italic>n<\/jats:italic>\u00a0=\u00a020), normal pregnancy (<jats:italic>n<\/jats:italic>\u00a0=\u00a060), and non\u2010pregnancy (<jats:italic>n<\/jats:italic>\u00a0=\u00a020) controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">EOPE<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HELLP<\/jats:styled-content>s had significantly increased <jats:styled-content style=\"fixed-case\">CMV I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content> sero\u2010positivity, upregulated <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>\u20102\/\u20104 m<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> expression, increased serum <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 and <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1, and reduced <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 compared with matched normal and non\u2010pregnancy controls. No significant difference was observed between <jats:styled-content style=\"fixed-case\">LOPE<\/jats:styled-content> and normal pregnancy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We observed a significant association between <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> IgG sero\u2010positivity and innate immune response in <jats:styled-content style=\"fixed-case\">EOPE<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HELLP<\/jats:styled-content>s. Our data suggest that <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> infection may be a risk factor for this disorder.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12199","type":"journal-article","created":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T18:19:03Z","timestamp":1393265943000},"page":"379-386","source":"Crossref","is-referenced-by-count":32,"title":["<scp>CMV<\/scp> Infection, <scp>TLR<\/scp>\u20102 and \u20104 Expression, and Cytokine Profiles in Early\u2010Onset Preeclampsia with <scp>HELLP<\/scp> Syndrome"],"prefix":"10.1111","volume":"71","author":[{"given":"Fang","family":"Xie","sequence":"first","affiliation":[{"name":"Pacific Northwest Research Institute Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"von Dadelszen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology the Child and Family Research Institute University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Nadeau","sequence":"additional","affiliation":[{"name":"Pacific Northwest Research Institute Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)17987-2"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1111726"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03577-7"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1081\/PRG-120021060"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-9-8"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/95.6.343"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp236"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2006.00468.x"},{"key":"e_1_2_8_10_1","first-page":"12","article-title":"[Cytomegalovirus infection in immunocompetent patients. 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