{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T04:13:20Z","timestamp":1774671200043,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,3,14]],"date-time":"2014-03-14T00:00:00Z","timestamp":1394755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>To determine the interplay between fetal antigenicity and local maternal factors in determining reproductive tract T regulatory (Treg) cell accumulation during pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>Examination of maternal Treg composition in the uterus, cervix, and uteroplacental interface (<jats:styled-content style=\"fixed-case\">UPI<\/jats:styled-content>) of murine syngeneic and allogeneic pregnancies and non\u2010pregnant controls by flow cytometry. The impact of fetal antigenicity was defined by either fetal gender in syngeneic pregnancies or by allogeneic paternity. Impact of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 on local Treg composition was determined using syngeneic pregnancies in <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106<jats:sup>\u2212\/\u2212<\/jats:sup> females.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An increased fraction of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> T cells in the pregnant uterine lymphocytic infiltrate and draining pelvic lymph nodes are Tregs. Maternal <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 decreases Treg accumulation within the uterus and to a greater extent in the cervix in syngeneic pregnancy. Fetal antigenicity is matched by accumulation of Tregs to the <jats:styled-content style=\"fixed-case\">UPI<\/jats:styled-content>. Treg accumulation at the <jats:styled-content style=\"fixed-case\">UPI<\/jats:styled-content> of non\u2010antigenic female fetuses is determined by the intrauterine position relative to male siblings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Reproductive tract tissue Treg composition during pregnancy is influenced by maternal <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 and fetal antigenicity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12223","type":"journal-article","created":{"date-parts":[[2014,3,14]],"date-time":"2014-03-14T10:36:13Z","timestamp":1394793373000},"page":"391-400","source":"Crossref","is-referenced-by-count":5,"title":["Maternal and Fetal Factors that Contribute to the Localization of T Regulatory Cells During Pregnancy"],"prefix":"10.1111","volume":"71","author":[{"given":"Carrie M.","family":"Wambach","sequence":"first","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility 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